Changes in lipids composition and metabolism in colorectal cancer: a review

Alicja Pakiet , Jarosław Kobiela , Piotr Stepnowski , Tomasz Śledziński , Adriana Mika

Abstract

Altered metabolism of lipids is currently considered a hallmark characteristic of many malignancies, including colorectal cancer (CRC). Lipids are a large group of metabolites that differ in terms of their fatty acid composition. This review summarizes recent evidence, documenting many alterations in the content and composition of fatty acids, polar lipids, oxylipins and triacylglycerols in CRC patients’ sera, tumor tissues and adipose tissue. Some of altered lipid molecules may be potential biomarkers of CRC risk, development and progression. Owing to a significant role of many lipids in cancer cell metabolism, some of lipid metabolism pathways may also constitute specific targets for anti-CRC therapy.
Author Alicja Pakiet (FCh / DEA / LChER)
Alicja Pakiet,,
- Laboratory of Chemical Environmental Risks
, Jarosław Kobiela
Jarosław Kobiela,,
-
, Piotr Stepnowski (FCh / DEA / LChER)
Piotr Stepnowski,,
- Laboratory of Chemical Environmental Risks
, Tomasz Śledziński
Tomasz Śledziński,,
-
, Adriana Mika (FCh / DEA / LChER)
Adriana Mika,,
- Laboratory of Chemical Environmental Risks
Journal seriesLipids in Health and Disease, ISSN 1476-511X, (A 25 pkt)
Issue year2019
Vol18
Pages1-21
Publication size in sheets1
Keywords in EnglishColorectal cancer, polar lipids, oxylipins, fatty acids, lipidomics, metabolism
DOIDOI:10.1186/s12944-019-0977-8
URL https://doi.org/10.1186/s12944-019-0977-8
Languageen angielski
LicenseJournal (articles only); published final; Uznanie Autorstwa (CC-BY); with publication
Score (nominal)25
ScoreMinisterial score = 25.0, ArticleFromJournal
Ministerial score (2013-2016) = 25.0, ArticleFromJournal
Publication indicators WoS Impact Factor: 2017 = 2.663 (2) - 2017=2.707 (5); WoS Citations = 0
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