Efficient synthesis and antifungal investigation of nucleosides’ quaternary ammonium salt derivatives
Barbara Dmochowska , Lucyna Pellowska-Januszek , Justyna Samaszko-Fiertek , Rafał Ślusarz , Roland Wakieć , Janusz Madaj
AbstractQuaternary ammonium salts are a group of compounds with diverse biological properties, the most importantof which are their antiviral, antibacterial, and antifungal activities. The quaternization reactions of 5'-O-tosyl derivativesof uridine and thymidine with triethylamine, trimethylamine, 4-(N,N-dimethylamino)pyridine, 2-methylpyridine, andpyridine are described in this article. Two of the synthesized compounds are exceptional because they are first of thistype that demonstrate concentration-dependent antifungal in vitro activity against two species of the genusCandidain minimal YNB-SG medium. The experimental results have been extended by adding full atom molecular dynamicssimulations and substrates and products energies evaluation.
|Journal series||Turkish Journal of Chemistry, ISSN 1300-0527, (N/A 40 pkt)|
|Publication size in sheets||0.70|
|Keywords in English||Quaternary ammonium salts, uridine-5'-ammonium derivatives, thymidine-5'-ammonium derivatives|
|License||Journal (articles only); published final; ; with publication|
|Score||= 40.0, 28-01-2020, ArticleFromJournal|
|Publication indicators||= 0.000; : 2016 = 0.616; : 2018 = 1.000 (2) - 2018=1.168 (5)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.