Efficient synthesis and antifungal investigation of nucleosides’ quaternary ammonium salt derivatives
Barbara Dmochowska , Lucyna Pellowska-Januszek , Justyna Samaszko-Fiertek , Rafał Ślusarz , Roland Wakieć , Janusz Madaj
AbstractQuaternary ammonium salts are a group of compounds with diverse biological properties, the most importantof which are their antiviral, antibacterial, and antifungal activities. The quaternization reactions of 5'-O-tosyl derivativesof uridine and thymidine with triethylamine, trimethylamine, 4-(N,N-dimethylamino)pyridine, 2-methylpyridine, andpyridine are described in this article. Two of the synthesized compounds are exceptional because they are first of thistype that demonstrate concentration-dependent antifungal in vitro activity against two species of the genusCandidain minimal YNB-SG medium. The experimental results have been extended by adding full atom molecular dynamicssimulations and substrates and products energies evaluation.
|Journal series||Turkish Journal of Chemistry, ISSN 1300-0527, (A 20 pkt)|
|Publication size in sheets||0.7|
|Keywords in English||Quaternary ammonium salts, uridine-5'-ammonium derivatives, thymidine-5'-ammonium derivatives|
|License||Journal (articles only); published final; ; with publication|
|Score||= 20.0, 24-07-2019, ArticleFromJournal|
|Publication indicators||= 0; : 2016 = 0.616; : 2017 = 1.377 (2) - 2017=1.342 (5)|
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