Solvatochromism of antiinflammatory drug - naproxen sodium

Marta Miotke , Marek Józefowicz


The influence of non-specific and specific solute-solvent interactions on the popular nonsteroidal antiinflammatory drug – naproxen sodium (NAP) – solvatochromism has been studied using steady-state spectroscopic technique combined with quantum-chemical modeling. To interpret the microenvironment (solvent) effects, the established linear solvation energy relationships of Kamlet-Taft and the improved Catalán scales are used. This analysis reveals that NAP solvation is mainly determined by dipolar interactions, whereas the specific interactions play a less significant role. To gain a deeper insight into the electronic and optical properties of the investigated dye the difference in the ground and excited state dipole moments was determined using the theory of solvatochromism and compared with quantum-chemical calculations. Finally, the influence of polarizability on the determined dipole moments was analyzed.
Author Marta Miotke (FMPI / IEP)
Marta Miotke ,,
- Institute of Experimental Physics
, Marek Józefowicz (FMPI / IEP)
Marek Józefowicz,,
- Institute of Experimental Physics
Other language title versions
Journal seriesJournal of Molecular Liquids, ISSN 0167-7322, (A 30 pkt)
Issue year2017
Publication size in sheets0.5
Keywords in Englishnaproxen sodium, solvent effects, excited-state dipole moment, hydrogen bond
ASJC Classification2505 Materials Chemistry; 1606 Physical and Theoretical Chemistry; 1607 Spectroscopy; 3104 Condensed Matter Physics; 3107 Atomic and Molecular Physics, and Optics; 2504 Electronic, Optical and Magnetic Materials
Languageen angielski
Score (nominal)30
Score sourcejournalList
ScoreMinisterial score = 30.0, 26-05-2020, ArticleFromJournal
Publication indicators WoS Citations = 10; Scopus SNIP (Source Normalised Impact per Paper): 2017 = 1.23; WoS Impact Factor: 2017 = 4.513 (2) - 2017=3.929 (5)
Citation count*14 (2020-05-21)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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