The role of the Val57 amino-acid residue in the hinge loop of the human cystatin C. Conformational studies of the β2-L1-β3 segments of sild-type human cystatin C and its mutants

Sylwia Rodziewicz-Motowidło , Justyna Iwaszkiewicz , Renata Sosnowska , Paulina Czaplewska , Emil Sobolewski , Aneta Szymańska , Krystyna Stachowiak , Józef Adam Liwo

Abstract

n/a
Author Sylwia Rodziewicz-Motowidło (FCh / DBCh / LMCh)
Sylwia Rodziewicz-Motowidło,,
- Laboratory of Medical Chemistry
, Justyna Iwaszkiewicz (FCh / DTCh)
Justyna Iwaszkiewicz,,
- Department of Theoretical Chemistry
, Renata Sosnowska (FCh / DBCh)
Renata Sosnowska,,
- Department of Biomedical Chemistry
, Paulina Czaplewska (IFB / M020 / DMCB)
Paulina Czaplewska,,
- Department of Molecular and Cellular Biology
, Emil Sobolewski (IFB)
Emil Sobolewski,,
- Intercollegiate Faculty of Biotechnology UG
, Aneta Szymańska (FCh / DBCh / LMCh)
Aneta Szymańska,,
- Laboratory of Medical Chemistry
, Krystyna Stachowiak (FCh / DBCh / LMCh)
Krystyna Stachowiak,,
- Laboratory of Medical Chemistry
, Józef Adam Liwo (FCh / DTCh / LMM)
Józef Adam Liwo,,
- Laboratory of Molecular Modeling
Journal seriesBiopolymers, ISSN 0006-3525, e-ISSN 1097-0282, (A 25 pkt)
Issue year2009
Vol91
No5
Pages273-383
Keywords in Englishhuman cystatin C (HCC), hinge loop; β-hairpin, circular dichroism (CD), potential of mean force (PMF), molecular dynamics (MD), point mutations
DOIDOI:10.1002/bip.21140
URL http://onlinelibrary.wiley.com/doi/10.1002/bip.21140/pdf
Languageen angielski
Score (nominal)25
Publication indicators WoS Impact Factor: 2009 = 2.605 (2) - 2009=2.474 (5)
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