Metallopharmaceuticals in therapy - a new horizon for scientific research

Agnieszka Chylewska , Małgorzata Biedulska , Przemysław Sumczyński , Mariusz Makowski

Abstract

Coordination chemistry offers much scope for the design of novel and therapeutic agents, including metallopharmaceuticals. The widespread use of metal complexes as effective pharmaceuticals, e.g. cancer therapeutic, anti-inflammatory, antidiabetic drugs or antimicrobial and diagnostic agents, demonstrates that the cytotoxicity of metal ions can be finely controlled via the appropriate choice of ligands. The successful targeting of radioisotopes again depends on the ligand design and metal oxidation state. The complexes of platinum, ruthenium, cobalt, copper and other d-block metal ions have been used in medicine for a long time but only recent advances have been made in understanding the molecular basis of mechanism of their action. Due to the above mentioned purpose, we decided to prepare a detailed description of target-based research, directed towards a design and application possibilities, with the known mechanisms of action of metal ion complexes in the broad sense of therapy definition. The review also covers the progress, limitations and challenges of the above-mentioned approaches and emphasizes the advantages of well known and new metallopharmaceuticals in medicine and pharmacy.
Author Agnieszka Chylewska POM
Agnieszka Chylewska,,
- Laboratory of Intermolecular Interactions
, Małgorzata Biedulska POM
Małgorzata Biedulska,,
- Laboratory of Intermolecular Interactions
, Przemysław Sumczyński POM
Przemysław Sumczyński,,
- Laboratory of Intermolecular Interactions
, Mariusz Makowski POM
Mariusz Makowski,,
- Laboratory of Intermolecular Interactions
Journal seriesCurrent Medicinal Chemistry, ISSN 0929-8673
Issue year2018
Vol25
No15
Pages1729-1791
Keywords in Englishmetallopharmaceuticals, coordination compounds, cancer therapeutic drugs, antimicrobial agents, medical diagnosis, mechanisms of activities
DOIDOI:10.2174/0929867325666171206102501
Languageen angielski
Score (nominal)40
ScoreMinisterial score = 35.0, 09-02-2018, ArticleFromJournal
Ministerial score (2013-2016) = 40.0, 09-02-2018, ArticleFromJournal
Publication indicators WoS Impact Factor: 2016 = 3.249 (2) - 2016=3.508 (5)
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