Metallopharmaceuticals in therapy - a new horizon for scientific research

Agnieszka Chylewska , Małgorzata Biedulska , Przemysław Sumczyński , Mariusz Makowski


Coordination chemistry offers much scope for the design of novel and therapeutic agents, including metallopharmaceuticals. The widespread use of metal complexes as effective pharmaceuticals, e.g. cancer therapeutic, anti-inflammatory, antidiabetic drugs or antimicrobial and diagnostic agents, demonstrates that the cytotoxicity of metal ions can be finely controlled via the appropriate choice of ligands. The successful targeting of radioisotopes again depends on the ligand design and metal oxidation state. The complexes of platinum, ruthenium, cobalt, copper and other d-block metal ions have been used in medicine for a long time but only recent advances have been made in understanding the molecular basis of mechanism of their action. Due to the above mentioned purpose, we decided to prepare a detailed description of target-based research, directed towards a design and application possibilities, with the known mechanisms of action of metal ion complexes in the broad sense of therapy definition. The review also covers the progress, limitations and challenges of the above-mentioned approaches and emphasizes the advantages of well known and new metallopharmaceuticals in medicine and pharmacy.
Author Agnieszka Chylewska (FCh / KChBionieorg. / LII)
Agnieszka Chylewska,,
- Laboratory of Intermolecular Interactions
, Małgorzata Biedulska (FCh / KChBionieorg. / LII)
Małgorzata Biedulska,,
- Laboratory of Intermolecular Interactions
, Przemysław Sumczyński (FCh / KChBionieorg. / LII)
Przemysław Sumczyński,,
- Laboratory of Intermolecular Interactions
, Mariusz Makowski (FCh / KChBionieorg. / LII)
Mariusz Makowski,,
- Laboratory of Intermolecular Interactions
Journal seriesCurrent Medicinal Chemistry, ISSN 0929-8673, (A 40 pkt)
Issue year2018
Keywords in Englishmetallopharmaceuticals, coordination compounds, cancer therapeutic drugs, antimicrobial agents, medical diagnosis, mechanisms of activities
ASJC Classification3004 Pharmacology; 1313 Molecular Medicine
Languageen angielski
Score (nominal)40
Score sourcejournalList
ScoreMinisterial score = 40.0, 20-03-2020, ArticleFromJournal
Publication indicators WoS Citations = 4; Scopus Citations = 5; Scopus SNIP (Source Normalised Impact per Paper): 2018 = 0.979; WoS Impact Factor: 2018 = 3.894 (2) - 2018=3.693 (5)
Citation count*8 (2020-03-22)
Share Share

Get link to the record

* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
Are you sure?