Abnormal sphingolipid world in inflammation specific for lysosomal storage diseases and skin disorders

Marta Moskot , Katarzyna Bocheńska , Joanna Jakóbkiewicz-Banecka , Bogdan Banecki , Magdalena Gabig-Cimińska


Research in recent years has shown that sphingolipids are essential signalling molecules for the proper biological and structural functioning of cells. Long-term studies on the metabolism of sphingolipids have provided evidence for their role in the pathogenesis of a number of diseases. As many inflammatory diseases, such as lysosomal storage disorders and some dermatologic diseases, including psoriasis, atopic dermatitis and ichthyoses, are associated with the altered composition and metabolism of sphingolipids, more studies precisely determining the responsibilities of these compounds for disease states are required to develop novel pharmacological treatment opportunities. It is worth emphasizing that knowledge from the study of inflammatory metabolic diseases and especially the possibility of their treatment may lead to insight into related metabolic pathways, including those involved in the formation of the epidermal barrier and providing new approaches towards workable therapies.
Author Marta Moskot (FB / DMBG)
Marta Moskot,,
- Katedra Biologii i Genetyki Medycznej
, Katarzyna Bocheńska (FB / DMBG)
Katarzyna Bocheńska ,,
- Katedra Biologii i Genetyki Medycznej
, Joanna Jakóbkiewicz-Banecka (FB / DMBG)
Joanna Jakóbkiewicz-Banecka,,
- Katedra Biologii i Genetyki Medycznej
, Bogdan Banecki (IFB / M020 / DMCB)
Bogdan Banecki,,
- Department of Molecular and Cellular Biology
, Magdalena Gabig-Cimińska (FB / DMBG) - [Polish Academy of Science]
Magdalena Gabig-Cimińska,,
- Katedra Biologii i Genetyki Medycznej
- Polska Akademia Nauk
Journal seriesInternational Journal of Molecular Sciences, ISSN 1661-6596, e-ISSN 1422-0067, (A 30 pkt)
Issue year2018
Publication size in sheets1.35
Article number247
Keywords in Englishsphingolipid metabolism alterations, inflammatory diseases, lysosomal storage diseases, skin disorders, treatments, workable therapies
URL http://www.mdpi.com/1422-0067/19/1/247/pdf
Languageen angielski
LicenseJournal (articles only); published final; Uznanie Autorstwa (CC-BY); with publication
Score (nominal)30
ScoreMinisterial score = 30.0, ArticleFromJournal
Ministerial score (2013-2016) = 30.0, ArticleFromJournal
Publication indicators WoS Impact Factor: 2017 = 3.687 (2) - 2017=3.878 (5); WoS Citations = 3
Citation count*
Share Share

Get link to the record

* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
Are you sure?