Abnormal sphingolipid world in inflammation specific for lysosomal storage diseases and skin disorders
Marta Moskot , Katarzyna Bocheńska , Joanna Jakóbkiewicz-Banecka , Bogdan Banecki , Magdalena Gabig-Cimińska
AbstractResearch in recent years has shown that sphingolipids are essential signalling molecules for the proper biological and structural functioning of cells. Long-term studies on the metabolism of sphingolipids have provided evidence for their role in the pathogenesis of a number of diseases. As many inflammatory diseases, such as lysosomal storage disorders and some dermatologic diseases, including psoriasis, atopic dermatitis and ichthyoses, are associated with the altered composition and metabolism of sphingolipids, more studies precisely determining the responsibilities of these compounds for disease states are required to develop novel pharmacological treatment opportunities. It is worth emphasizing that knowledge from the study of inflammatory metabolic diseases and especially the possibility of their treatment may lead to insight into related metabolic pathways, including those involved in the formation of the epidermal barrier and providing new approaches towards workable therapies.
|Journal series||International Journal of Molecular Sciences, ISSN 1661-6596, e-ISSN 1422-0067|
|Publication size in sheets||1.35|
|Keywords in English||sphingolipid metabolism alterations, inflammatory diseases, lysosomal storage diseases, skin disorders, treatments, workable therapies|
|License||Journal (articles only); published final; ; with publication|
|Score|| = 30.0, 05-06-2018, ArticleFromJournal|
= 30.0, 05-06-2018, ArticleFromJournal
|Publication indicators||: 2016 = 3.226 (2) - 2016=3.482 (5)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.