Abnormal sphingolipid world in inflammation specific for lysosomal storage diseases and skin disorders

Marta Moskot , Katarzyna Bocheńska , Joanna Jakóbkiewicz-Banecka , Bogdan Banecki , Magdalena Gabig-Cimińska

Abstract

Research in recent years has shown that sphingolipids are essential signalling molecules for the proper biological and structural functioning of cells. Long-term studies on the metabolism of sphingolipids have provided evidence for their role in the pathogenesis of a number of diseases. As many inflammatory diseases, such as lysosomal storage disorders and some dermatologic diseases, including psoriasis, atopic dermatitis and ichthyoses, are associated with the altered composition and metabolism of sphingolipids, more studies precisely determining the responsibilities of these compounds for disease states are required to develop novel pharmacological treatment opportunities. It is worth emphasizing that knowledge from the study of inflammatory metabolic diseases and especially the possibility of their treatment may lead to insight into related metabolic pathways, including those involved in the formation of the epidermal barrier and providing new approaches towards workable therapies.
Author Marta Moskot
Marta Moskot,,
-
, Katarzyna Bocheńska KBM
Katarzyna Bocheńska ,,
- Department of Molecular Biology
, Joanna Jakóbkiewicz-Banecka KBM
Joanna Jakóbkiewicz-Banecka,,
- Department of Molecular Biology
, Bogdan Banecki KBMiK
Bogdan Banecki,,
- Department of Molecular and Cellular Biology
, Magdalena Gabig-Cimińska
Magdalena Gabig-Cimińska,,
-
Journal seriesInternational Journal of Molecular Sciences, ISSN 1661-6596, e-ISSN 1422-0067
Issue year2018
Vol19
No1
Pages1-28
Publication size in sheets1.35
Keywords in Englishsphingolipid metabolism alterations, inflammatory diseases, lysosomal storage diseases, skin disorders, treatments, workable therapies
DOIDOI:10.3390/ijms19010247
URL http://www.mdpi.com/1422-0067/19/1/247/pdf
Languageen angielski
LicenseJournal (articles only); published final; Uznanie Autorstwa (CC-BY); with publication
Score (nominal)30
ScoreMinisterial score = 30.0, 05-06-2018, ArticleFromJournal
Ministerial score (2013-2016) = 30.0, 05-06-2018, ArticleFromJournal
Publication indicators WoS Impact Factor: 2016 = 3.226 (2) - 2016=3.482 (5)
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