Ionic liquids as signal amplifiers for the simultaneous extraction of several neurotransmitters determined by micellar electrokinetic chromatography

Natalia Miękus , Ilona Olędzka , Natalia Kossakowska , Alina Plenis , Piotr Kowalski , Adam Prahl , Tomasz Bączek

Abstract

Nowadays, ionic liquids (ILs) are receiving more attention in various fields of analytical chemistry. Their contribution to the enhancement of the clean-up, extraction, separation and determination of trace amounts of various biologically important compounds in distinct matrices is well documented. Moreover, their importance as "green chemistry" solvents has been pointed out. Advanced analytical methods based on the IL-assisted microextraction and electrophoretic determination of minute concentrations of neurotransmitters (NTs) in samples are presented here for the first time. In this paper, experimental data showed the usefulness of the chosen imidazolium-based ILs in solid-phase microextraction (SPME), followed by the micellar electrokinetic chromatography (MEKC) determination of three biogenic amines: dopamine, noradrenaline and adrenaline together with such amino acids as L-tyrosine and L-tryptophan. A significant increase in SPME yields, using 1-ethyl-3- methylimidazolium tetrafluoroborate as a component of the desorbent, allowing from 9 to 21 times the signal enhancement for the selected NTs, has been achieved. The elaborated IL-based SPME procedures might serve as a straightforward analytical platform for the unbiased analysis of NTs as biomarkers of various diseases where an unbalanced secretion of NTs is registered.
Author Natalia Miękus (FB / DAHP)
Natalia Miękus,,
- Department of Animal and Human Physiology
, Ilona Olędzka
Ilona Olędzka,,
-
, Natalia Kossakowska
Natalia Kossakowska,,
-
, Alina Plenis
Alina Plenis,,
-
, Piotr Kowalski
Piotr Kowalski,,
-
, Adam Prahl (FCh / DOCh / LChB)
Adam Prahl,,
- Laboratory of Chemistry of Biopolymers
, Tomasz Bączek
Tomasz Bączek,,
-
Journal seriesTalanta, ISSN 0039-9140, (A 40 pkt)
Issue year2018
Vol186
Pages119-123
Publication size in sheets0.5
Keywords in Englishionic liquids, neurotransmitters, micellar electrokinetic chromatography (MEKC), solid-phase microextraction (SPME), urine samples
DOIDOI:10.1016/j.talanta.2018.04.041
URL https://doi.org/10.1016/j.talanta.2018.04.041
Languageen angielski
Score (nominal)40
ScoreMinisterial score = 40.0, 26-04-2018, ArticleFromJournal
Ministerial score (2013-2016) = 40.0, 26-04-2018, ArticleFromJournal
Publication indicators WoS Impact Factor: 2016 = 4.162 (2) - 2016=3.841 (5)
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