Contamination of the southern Baltic Sea waters by the residues of selected pharmaceuticals: method development and field studies

Marta Borecka , Grzegorz Siedlewicz , Łukasz Haliński , Kinga Sikora , Ksenia Pazdro , Piotr Stepnowski , Anna Białk-Bielińska


In this study the occurrence of thirteen pharmaceuticals in seawaters collected from southern Baltic Sea was evaluated for the first time. It was performed by applying newly developed analytical procedure. The method was characterized in terms of its basic validation parameters as well as matrix effects, extraction efficiency and absolute recovery. The results were expressed as result ± expanded uncertainty, which was estimated according to the Guide to the Expression of Uncertainty in Measurement. Additionally, in order to verify the influence of variable parameters of the analyzed samples on method performance parameters, chemometric analysis was carried out. The obtained results revealed that residues of pharmaceuticals were present in seawaters at a concentration level of ng L−1. Trimethoprim, sulfamethoxazole and enrofloxacin were most frequently detected compounds. The highest concentration was determined for ketoprofen (135.0 ± 10.9 ng L−1). Marine pollution potential hotspots were found in enclosed or semi-enclosed bodies of water.
Author Marta Borecka (FCh/DEA/LChER)
Marta Borecka,,
- Laboratory of Chemical Environmental Risks
, Grzegorz Siedlewicz - [Institute of Oceanology of the Polish Academy of Sciences]
Grzegorz Siedlewicz,,
- Institute of Oceanology of the Polish Academy of Sciences
, Łukasz Haliński (FCh/DEA/LANC)
Łukasz Haliński,,
- Laboratory of Analysis of Natural Compounds
, Kinga Sikora (FCh/PChW)
Kinga Sikora,,
- Physics-Chemistry Workshops
, Ksenia Pazdro - [Institute of Oceanology of the Polish Academy of Sciences]
Ksenia Pazdro,,
- Institute of Oceanology of the Polish Academy of Sciences
, Piotr Stepnowski (FCh/DEA/LChER)
Piotr Stepnowski,,
- Laboratory of Chemical Environmental Risks
, Anna Białk-Bielińska (FCh/DEA/LChER)
Anna Białk-Bielińska,,
- Laboratory of Chemical Environmental Risks
Journal seriesMarine Pollution Bulletin, ISSN 0025-326X, (A 40 pkt)
Issue year2015
Publication size in sheets0.50
Keywords in EnglishBaltic Sea, pharmaceutical residues, marine waters contamination, uncertainty estimation, matrix effects, LC-MS/MS
ASJC Classification2310 Pollution; 1104 Aquatic Science; 1910 Oceanography
Languageen angielski
Score (nominal)40
Score sourcejournalList
ScoreMinisterial score = 40.0, 31-07-2020, ArticleFromJournal
Ministerial score (2013-2016) = 40.0, 31-07-2020, ArticleFromJournal
Publication indicators Scopus Citations = 45.000; WoS Citations = 34.000; Scopus SNIP (Source Normalised Impact per Paper): 2015 = 1.276; WoS Impact Factor: 2015 = 3.099 (2) - 2015=3.512 (5)
Citation count*48 (2020-08-04)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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