B2 bradykinin receptor antagonists: adsorption mechanism on electrochemically roughened Ag substrate

Edyta Proniewicz , Dominika Skołuba , Andrzej Kudelski , Dariusz Sobolewski , Adam Prahl , Younkyoo Kim , Leonard M. Proniewicz

Abstract

In this paper, the surface‐enhanced Raman scattering (SERS) spectra of the potent B2 bradykinin receptor antagonists, [D‐Arg0,Hyp3,Thi5,8,L‐Pip7]BK, Aaa[D‐Arg0,Hyp3,Thi5,8,L‐Pip7]BK, [D‐Arg0,Hyp3,Thi5,D‐Phe7,L‐Pip8]BK, and Aaa[D‐Arg0,Hyp3,Thi5,D‐Phe7,L‐Pip8]BK, were measured when immobilized onto a highly specific electrochemically roughened SERS‐active Ag substrate characterized by the formation of a 50 – 150 nm Ag islands on its surface. The observed SERS bands corresponding to different vibrational modes of the molecule, attached to or near Ag, and the variations in these bands resulting from competitive interactions of the functional groups of the peptides with the SERS‐active Ag surfaces and reorientation occurring over time of adsorption were analyzed in this study.
Author Edyta Proniewicz
Edyta Proniewicz,,
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, Dominika Skołuba
Dominika Skołuba,,
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, Andrzej Kudelski
Andrzej Kudelski,,
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, Dariusz Sobolewski (FCh / DOCh / LChB)
Dariusz Sobolewski,,
- Laboratory of Chemistry of Biopolymers
, Adam Prahl (FCh / DOCh / LChB)
Adam Prahl,,
- Laboratory of Chemistry of Biopolymers
, Younkyoo Kim
Younkyoo Kim,,
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, Leonard M. Proniewicz
Leonard M. Proniewicz,,
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Journal seriesJournal of Raman Spectroscopy, ISSN 0377-0486, (A 30 pkt)
Issue year2013
Vol44
No2
Pages205-211
Publication size in sheets0.5
DOIDOI:10.1002/jrs.4182
URL http://onlinelibrary.wiley.com/doi/10.1002/jrs.4182/pdf
Languageen angielski
Score (nominal)30
ScoreMinisterial score = 30.0, 03-12-2018, ArticleFromJournal
Ministerial score (2013-2016) = 30.0, 03-12-2018, ArticleFromJournal
Publication indicators WoS Impact Factor: 2013 = 2.519 (2) - 2013=2.425 (5)
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