Bacteriophages as factories for Eu2O3 nanoparticle synthesis

Piotr Golec , Kamila Żelechowska , Joanna Karczewska-Golec , Jakub Karczewski , Adam Leśniewski , Marcin Łoś , Grzegorz Węgrzyn , Andrzej Marian Kłonkowski


The use of phage display to identify peptides with an ability to bind and synthesize Eu2O3 nanoparticles is demonstrated in this report. This is the first report of modified phages specifically binding a lanthanide. The peptides exposed on virions revealed very strong binding to Eu2O3 nanoparticles and the ability to catalyze Eu2O3 nanoparticles’ formation from Eu(OH)3 and Eu(NO3)3 solutions. The luminescence emission spectrum of Eu3+ ions indicated that these ions existed mostly in sites deviated from the inversion symmetry in crystalline Eu2O3 aggregates and gelatinous Eu(OH)3 precipitate. The ability of phage-displayed peptides to catalyze formation of Eu2O3 nanoparticles provides a useful tool for a low-cost and effective synthesis of lanthanide nanoparticles, which serve as attractive biomedical sensors or fluorescent labels, among their other applications.
Author Piotr Golec - [Uniwersytet Gdanski]
Piotr Golec,,
- Uniwersytet Gdanski
, Kamila Żelechowska - [Politechnika Gdanska]
Kamila Żelechowska,,
- Politechnika Gdanska
, Joanna Karczewska-Golec (FB / DMGB)
Joanna Karczewska-Golec,,
- Department of Molecular Genetics of Bacteria
, Jakub Karczewski - [Politechnika Gdanska]
Jakub Karczewski,,
- Politechnika Gdanska
, Adam Leśniewski - [Institute of Physical Chemistry of the Polish Academy of Sciences]
Adam Leśniewski,,
- Institute of Physical Chemistry of the Polish Academy of Sciences
, Marcin Łoś (FB / DMGB)
Marcin Łoś,,
- Department of Molecular Genetics of Bacteria
, Grzegorz Węgrzyn (FB / DMoB)
Grzegorz Węgrzyn,,
- Department of Molecular Biology
, Andrzej Marian Kłonkowski (FCh)
Andrzej Marian Kłonkowski,,
- Faculty of Chemistry
Journal seriesBioconjugate Chemistry, ISSN 1043-1802, (A 40 pkt)
Issue year2017
Publication size in sheets0.5
ASJC Classification1605 Organic Chemistry; 3003 Pharmaceutical Science; 3004 Pharmacology; 2204 Biomedical Engineering; 1502 Bioengineering; 1305 Biotechnology
Languageen angielski
Score (nominal)40
Score sourcejournalList
ScoreMinisterial score = 40.0, 29-05-2020, ArticleFromJournal
Publication indicators WoS Citations = 1; Scopus Citations = 1; Scopus SNIP (Source Normalised Impact per Paper): 2017 = 0.989; WoS Impact Factor: 2017 = 4.485 (2) - 2017=4.416 (5)
Citation count*1 (2020-05-12)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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