Re-evaluation of human BDCA-2+ DC during acute sterile skin inflammation

Yi-Ling Chen , Tomas Gomes , Clare S. Hardman , Felipe A. Vieira Braga , Danuta Gutowska-Owsiak , Maryam Salimi , Nicki Gray , David A. Duncan , Gary Reynolds , David Johnson , Mariolina Salio , Vincenzo Cerundolo , Jillian L. Barlow , Andrew N.J. McKenzie , Sarah A. Teichmann , Muzlifah Haniffa , Graham S. Ogg

Abstract

An unexpected BDCA-2+CD123+CD1a+ DC subset comprises a major DC population in acute human sterile skin inflammation. scRNA-seq shows these to be activated DCs able to express markers normally associated with plasmacytoid DCs, prompting a re-evaluation of previous studies.
Author Yi-Ling Chen
Yi-Ling Chen,,
-
, Tomas Gomes
Tomas Gomes,,
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, Clare S. Hardman
Clare S. Hardman,,
-
, Felipe A. Vieira Braga
Felipe A. Vieira Braga,,
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, Danuta Gutowska-Owsiak (IFB / M020 / DMCB)
Danuta Gutowska-Owsiak,,
- Department of Molecular and Cellular Biology
, Maryam Salimi
Maryam Salimi,,
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, Nicki Gray
Nicki Gray,,
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, David A. Duncan
David A. Duncan,,
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, Gary Reynolds
Gary Reynolds,,
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, David Johnson
David Johnson,,
-
et al.`
Journal seriesJournal of Experimental Medicine, ISSN 0022-1007, e-ISSN 1540-9538, (N/A 200 pkt)
Issue year2020
Vol217
No3
Pages1-14
Publication size in sheets0.65
Article numbere20190811
ASJC Classification2723 Immunology and Allergy; 2403 Immunology
DOIDOI:10.1084/jem.20190811
Languageen angielski
Score (nominal)200
Score sourcejournalList
ScoreMinisterial score = 200.0, 28-01-2020, ArticleFromJournal
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2018 = 2.143; WoS Impact Factor: 2018 = 10.892 (2) - 2018=11.897 (5)
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