Autoantibodies to heat shock proteins 60, 70, and 90 in patients with rheumatoid arthritis
Jagoda Mantej , Kinga Polasik , Ewa Piotrowska , Stefan Tukaj
AbstractHeat shock proteins (HSP) have been reported to impact immune responses and to be associated with rheumatoid arthritis (RA). Recently, we provided evidence for a role of autoantibodies to Hsp40 in patients with RA. In this study, we aimed at investigating the humoral autoimmune response to Hsp60, Hsp70, and Hsp90 in RA patients (n = 39). In comparison with healthy controls (n = 40), circulating IgG, IgM, and IgA autoantibodies against Hsp60, Hsp70, and Hsp90 were significantly increased in RA patients. Non-parametric statistical analysis, however, revealed no significant association between anti-HSP and disease activity or disease progression. On the other hand, positive correlations between serum levels of anti-Hsp60 IgG and IL-4 (Th2-like cytokine) or between serum levels of anti-Hsp90 IgG and IFN-ɣ (Th1-like cytokine) were found to be statistically significant in RA. In addition, a significant inverse correlation was found for serumlevels of anti-Hsp70 IgMand TNF-α (Th1-like cytokine) in RA. Our results suggest a pronounced anti-Hsp60, anti-Hsp70, and anti-Hsp90 humoral autoimmune response in RA patients that seems not to be directly linked to RA pathophysiology, however, may have a potential modulatory impact on inflammatory status in this disease. Further investigations are needed to clarify the role of anti-HSP autoantibodies in RA.
|Journal series||Cell Stress & Chaperones, ISSN 1355-8145, (N/A 70 pkt)|
|Publication size in sheets||0.5|
|Keywords in English||Heat shock proteins - HSP, rheumatoid arthritis - RA, autoantibodies|
|Score||= 70.0, 30-09-2019, ArticleFromJournal|
|Publication indicators||= 0; : 2016 = 0.799; : 2017 = 2.571 (2) - 2017=2.626 (5)|
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