Autoantibodies to heat shock proteins 60, 70, and 90 in patients with rheumatoid arthritis

Jagoda Mantej , Kinga Polasik , Ewa Piotrowska , Stefan Tukaj

Abstract

Heat shock proteins (HSP) have been reported to impact immune responses and to be associated with rheumatoid arthritis (RA). Recently, we provided evidence for a role of autoantibodies to Hsp40 in patients with RA. In this study, we aimed at investigating the humoral autoimmune response to Hsp60, Hsp70, and Hsp90 in RA patients (n = 39). In comparison with healthy controls (n = 40), circulating IgG, IgM, and IgA autoantibodies against Hsp60, Hsp70, and Hsp90 were significantly increased in RA patients. Non-parametric statistical analysis, however, revealed no significant association between anti-HSP and disease activity or disease progression. On the other hand, positive correlations between serum levels of anti-Hsp60 IgG and IL-4 (Th2-like cytokine) or between serum levels of anti-Hsp90 IgG and IFN-ɣ (Th1-like cytokine) were found to be statistically significant in RA. In addition, a significant inverse correlation was found for serumlevels of anti-Hsp70 IgMand TNF-α (Th1-like cytokine) in RA. Our results suggest a pronounced anti-Hsp60, anti-Hsp70, and anti-Hsp90 humoral autoimmune response in RA patients that seems not to be directly linked to RA pathophysiology, however, may have a potential modulatory impact on inflammatory status in this disease. Further investigations are needed to clarify the role of anti-HSP autoantibodies in RA.
Author Jagoda Mantej (FB / DMoB)
Jagoda Mantej,,
- Department of Molecular Biology
, Kinga Polasik (FB)
Kinga Polasik,,
- Faculty of Biology
, Ewa Piotrowska (FB / DMoB)
Ewa Piotrowska,,
- Department of Molecular Biology
, Stefan Tukaj (FB / DMoB)
Stefan Tukaj,,
- Department of Molecular Biology
Journal seriesCell Stress & Chaperones, ISSN 1355-8145, (A 20 pkt)
Issue year2019
Vol24
No1
Pages283-287
Publication size in sheets0.5
Keywords in EnglishHeat shock proteins - HSP, rheumatoid arthritis - RA, autoantibodies
DOIDOI:10.1007/s12192-018-0951-9
URL https://doi.org/10.1007/s12192-018-0951-9
Languageen angielski
Score (nominal)25
ScoreMinisterial score = 20.0, 28-02-2019, ArticleFromJournal
Ministerial score (2013-2016) = 25.0, 28-02-2019, ArticleFromJournal
Publication indicators WoS Impact Factor: 2017 = 2.571 (2) - 2017=2.626 (5)
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