Enzymes of the central carbon metabolism: are they linkers between transcription, DNA replication, and carcinogenesis?

Aleksandra Konieczna , Aneta Szczepańska , Karolina Sawiuk , Robert Łyżeń , Grzegorz Węgrzyn

Abstract

Dependence of carcinogenesis on disruption of DNA replication regulation is a well-known fact. There are also many reports demonstrating the interplay between transcription and DNA replication processes, particularly underlying the importance of promoter activities in the control of replication initiation. Recent findings have shown direct links between central carbon metabolism and DNA replication regulation. Here, we summarize previously published reports which indicated that enzymes of the central carbon metabolism, particularly those involved in glycolysis and the tricarboxylic acid cycle, may contribute to regulation of transcription and DNA transactions (replication and repair). In this light, we propose a hypothesis that some of these enzymes might be linkers between transcription, DNA replication, and carcinogenesis. If true, it may have a consequence in our understanding of causes and mechanisms of carcinogenesis. Particularly, certain metabolic perturbations might directly (through central carbon metabolism enzymes) influence regulation of DNA transactions (replication control and fidelity), and thus facilitate carcinogenesis. To test this hypothesis, further studies will be necessary, which is discussed in the final part of this article.
Author Aleksandra Konieczna (FB / DMoB)
Aleksandra Konieczna ,,
- Department of Molecular Biology
, Aneta Szczepańska (FB / DMoB)
Aneta Szczepańska,,
- Department of Molecular Biology
, Karolina Sawiuk (FB / DMoB)
Karolina Sawiuk,,
- Department of Molecular Biology
, Robert Łyżeń (FB / DMoB)
Robert Łyżeń,,
- Department of Molecular Biology
, Grzegorz Węgrzyn (FB / DMoB)
Grzegorz Węgrzyn,,
- Department of Molecular Biology
Journal seriesMedical Hypotheses, ISSN 0306-9877, (A 15 pkt)
Issue year2015
Vol84
No1
Pages58-67
Publication size in sheets0.5
DOIDOI:10.1016/j.mehy.2014.11.016
URL http://dx.doi.org/10.1016/j.mehy.2014.11.016
Languageen angielski
Score (nominal)15
ScoreMinisterial score = 15.0, 20-12-2017, ArticleFromJournal
Ministerial score (2013-2016) = 15.0, 20-12-2017, ArticleFromJournal
Publication indicators WoS Impact Factor: 2015 = 1.136 (2) - 2015=1.111 (5)
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