Therapy with CD4+CD25+ T regulatory cells - should we be afraid of cancer?

Mateusz Gliwiński , Magdalena Piotrowska , Dorota Iwaszkiewicz-Grześ , Zuzanna Urban-Wójciuk , Piotr Trzonkowski

Abstract

This review focuses on the role of regulatory T cells (Tregs) in the process of carcinogenesis. The controversy of this issue arose due to the increasing therapeutic use of Tregs in humans (inter alia, in the treatment of autoimmune diseases). It is mainly due to potential dangers related to immunosuppressive activity of these cells, especially regarding cancer. The natural function of regulatory T cells (which is the suppression of excessive activity of the immune system) is purportedly linked to an increased risk of cancer initiation. This work brings together and summarizes the most important reports of researchers dealing with this problem and attempts to explain doubts and fears related to Tregs and their uncertain connection with cancer initiation and progression. It is clearly shown that regulatory T cells are associated with acceleration of existing tumors (they are attracted by microenvironments created by cancer cells) but cannot initiate them on their own.
Author Mateusz Gliwiński
Mateusz Gliwiński,,
-
, Magdalena Piotrowska
Magdalena Piotrowska,,
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, Dorota Iwaszkiewicz-Grześ
Dorota Iwaszkiewicz-Grześ,,
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, Zuzanna Urban-Wójciuk (ICCVS)
Zuzanna Urban-Wójciuk,,
- International Centre for Cancer Vaccine Science
, Piotr Trzonkowski
Piotr Trzonkowski,,
-
Journal seriesWspółczesna Onkologia, ISSN 1428-2526, e-ISSN 1897-4309, (N/A 40 pkt)
Issue year2019
Vol23
No1
Pages1-6
Publication size in sheets0.5
Keywords in EnglishT regulatory cells, immunotherapy, cancer, immunosuppression, tumor induction
ASJC Classification2741 Radiology Nuclear Medicine and imaging; 2730 Oncology
DOIDOI:10.5114/wo.2019.84110
URL https://doi.org/10.5114/wo.2019.84110
Languageen angielski
Score (nominal)40
Score sourcejournalList
ScoreMinisterial score = 40.0, 28-01-2020, ArticleFromJournal
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2018 = 0.579; WoS Impact Factor: 2013 = 0.215 (2) - 2013=0.15 (5)
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