Disorders of serum polyunsaturated fatty acids in renal transplant patients

Malgorzata Sikorska-Wisniewska , Adriana Mika , Tomasz Śledziński , Monika Czaplińska , Sylwia Malgorzewicz , Alicja Debska-Slizien , Michał Chmielewski


Background. Disturbances in polyunsaturated fatty acids (PUFA) could predispose renal transplant (RTx) patients to cardiovascular risk. The purpose of this study was to evaluate serum content of u-3 and u-6 PUFA in RTx subjects, in comparison to nontransplanted chronic kidney disease (CKD) patients in predialysis stages and to healthy controls. In the second part of the study, PUFA were analyzed in subcutaneous adipose tissue of CKD subjects at the time of kidney transplantation. Methods. The first part of the study was conducted in a cohort (n ¼ 134) of 3 groups: patients after renal transplantation (RTx group, n¼24), patients with CKD in stages 2-5, not on dialysis (CKD-NDgroup, n¼67), and controls withoutCKD(control group, n¼43). The fatty acids (FA) assessed by gas chromatography-mass spectrometry (GC-MS) were alphalinolenic acid (ALA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), linoleic acid (LA), and arachidonic acid (AA). Diet was assessed by food frequency questionnaire FFQ-6. In the second part of the study, the same FA were evaluated in samples of adipose tissue taken during the kidney transplantation procedure and compared with FA of controls from the adipose tissue collected during hernia surgeries. Results. The first part of the study showed that RTx patients presented significantly lower serum content of all the examined PUFA, in comparison to the CKD-ND group and controls. For instance, EPA in RTx equaled 0.65 +_ 0.32%, in CKD-ND 0.82 +_ 0.43%, and in controls 1.06+_0.68%(P¼.005).Nosignificant correlations were found between serumPUFAand diet in RTx patients. The second part of the study revealed no significant difference in the adipose tissue PUFA between CKD patients at the time of kidney transplantation and controls. Conclusions. RTx patients present with low serum content of potentially beneficial PUFA. This finding does not seem to be solely due to an altered diet. Observed disorders might result from immunosuppressive drugs or other, yet undetermined, causes.
Publication typeIn press (online first, early view)
Author Malgorzata Sikorska-Wisniewska
Malgorzata Sikorska-Wisniewska,,
, Adriana Mika (FCh/DEA/LChER) - [Medical Uniwersity of Gdańsk (GUMed)]
Adriana Mika,,
- Laboratory of Chemical Environmental Risks
- Gdański Uniwersytet Medyczny
, Tomasz Śledziński
Tomasz Śledziński,,
, Monika Czaplińska
Monika Czaplińska,,
, Sylwia Malgorzewicz
Sylwia Malgorzewicz,,
, Alicja Debska-Slizien
Alicja Debska-Slizien,,
, Michał Chmielewski
Michał Chmielewski,,
Journal seriesTransplantation Proceedings, ISSN 0041-1345, e-ISSN 1873-2623, (N/A 40 pkt)
Issue year2020
Noonline first
Publication size in sheets0.50
ASJC Classification2746 Surgery; 2747 Transplantation
URL https://doi.org/10.1016/j.transproceed.2020.01.106
Languageen angielski
Sikorska_Wisniewska_Malgorzata_Disorders_of_serum_2020.pdf 333,58 KB
Score (nominal)40
Score sourcejournalList
ScoreMinisterial score = 40.0, 13-05-2020, ArticleFromJournal
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2017 = 0.445; WoS Impact Factor: 2018 = 0.959 (2) - 2018=1.058 (5)
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