Mechanism of water dynamics in Hyaluronic dermal fillers revealed by nuclear magnetic resonance relaxometry

Danuta Kruk , Paweł Rochowski , Elżbieta Masiewicz , Sławomir Wilczyński , Miłosz Wojciechowski , Lionel M. Broche , David J. Lurie

Abstract

1 H spin-lattice nuclear magnetic resonance relaxation experiments were performed for five kinds of dermal fillers based on hyaluronic acid. The relaxation data were collected over a broad frequency range between 4 kHz and 40 MHz, at body temperature. Thanks to the frequency range encompassing four orders of magnitude, the dynamics of water confined in the polymeric matrix was revealed. It is demonstrated that translation diffusion of the confined water molecules exhibits a two-dimensional character and the diffusion process is slower than diffusion in bulk water by 3-4 orders of magnitude. As far as rotational dynamics of the confined water is concerned, it is shown that in all cases there is a water pool characterized by a rotational correlation time of about 4*10-9  s. In some of the dermal fillers a fraction of the confined water (about 10%) forms a pool that exhibits considerably slower (by an order of magnitude) rotational dynamics. In addition, the water binding capacity of the dermal fillers was quantitatively compared.
Author Danuta Kruk
Danuta Kruk,,
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, Paweł Rochowski (FMPI / IEP)
Paweł Rochowski,,
- Institute of Experimental Physics
, Elżbieta Masiewicz
Elżbieta Masiewicz,,
-
, Sławomir Wilczyński
Sławomir Wilczyński,,
-
, Miłosz Wojciechowski
Miłosz Wojciechowski,,
-
, Lionel M. Broche
Lionel M. Broche,,
-
, David J. Lurie
David J. Lurie,,
-
Journal seriesChemPhysChem, ISSN 1439-4235, e-ISSN 1439-7641, (N/A 100 pkt)
Issue year2019
Vol20
No21
Pages2816-2822
Publication size in sheets0.5
Keywords in Englishdiffusion, gels, molecular dynamics, nuclear magnetic resonance, relaxation
ASJC Classification1606 Physical and Theoretical Chemistry; 3107 Atomic and Molecular Physics, and Optics
DOIDOI:10.1002/cphc.201900761
URL https://onlinelibrary.wiley.com/doi/epdf/10.1002/cphc.201900761
Languageen angielski
Score (nominal)100
Score sourcejournalList
ScoreMinisterial score = 100.0, 28-01-2020, ArticleFromJournal
Publication indicators WoS Citations = 0; Scopus SNIP (Source Normalised Impact per Paper): 2018 = 0.726; WoS Impact Factor: 2018 = 3.077 (2) - 2018=2.924 (5)
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