Coordination chemistry of pyrazine derivatives analogues of PZA: design, synthesis, characterization and biological activity

Małgorzata Ogryzek , Agnieszka Chylewska , Aleksandra Królicka , Rafał Banasiuk , Katarzyna Turecka , Dorota Lesiak , Dawid Nidzworski , Mariusz Makowski

Abstract

Ru(III) complexes with pyrazine derivatives: 2,3-bis(2-pyridyl)pyrazine (DPP), pyrazine-2-amidoxime (PAOX), pyrazine-2-thiocarboxamide (PTCA) and 2-amino-5-bromo-3-(methylamino)pyrazine (ABMAP) have been prepared. Characterization of the compounds was acquired using UV-Vis and FT-IR spectroscopy, elemental analysis, conductivity and electrochemical measurements as well as thermogravimetric studies. The ligand field parameters, Δ0 (splitting parameter), B (Racah parameter of interelectronic repulsion) and β (nephelauxetic ratio) were calculated. The stabilities of the Ru(III) complexes have also been confirmed by spectrophotometric titration methods in acetonitrile and water solutions. The data showed that the examined compounds are stable both in solution and solid states, which was also confirmed by the values of their stability constants found. Moreover, the molecular structures of the complexes have been optimized using AM1 and PM3 methods and this supported octahedral geometry around the Ru(III) ion. The minimum inhibitory (MIC) and minimum bactericidal concentration (MBC) for synthesized complexes were studied against two Gram (+) bacteria, two Gram (−) bacteria and fungi – three reference strains of Candida albicans. The results show that [RuCl(PAOX)2(OH2)]Cl2 display antifungal activity.
Author Małgorzata Ogryzek POM
Małgorzata Ogryzek,,
- Laboratory of Intermolecular Interactions
, Agnieszka Chylewska POM
Agnieszka Chylewska,,
- Laboratory of Intermolecular Interactions
, Aleksandra Królicka KB
Aleksandra Królicka,,
- Department of Biotechnology
, Rafał Banasiuk KB
Rafał Banasiuk,,
- Department of Biotechnology
, Katarzyna Turecka
Katarzyna Turecka,,
-
, Dorota Lesiak ZBMW
Dorota Lesiak,,
- Laboratory of Virus Molecular Biology
, Dawid Nidzworski ZSzR
Dawid Nidzworski,,
- Laboratory of Recombinant Vaccines
, Mariusz Makowski POM
Mariusz Makowski,,
- Laboratory of Intermolecular Interactions
Journal seriesRSC Advances, ISSN 2046-2069
Issue year2016
Vol6
No57
Pages52009-52025
Publication size in sheets0.8
DOIDOI:10.1039/c6ra03068h
URL http://pubs.rsc.org/en/content/articlepdf/2016/ra/c6ra03068h
Languageen angielski
LicenseJournal (articles only); published final; Uznanie Autorstwa - Użycie Niekomercyjne (CC-BY-NC); with publication
Score (nominal)35
ScoreMinisterial score = 30.0, 20-12-2017, ArticleFromJournal
Ministerial score (2013-2016) = 35.0, 20-12-2017, ArticleFromJournal
Publication indicators WoS Impact Factor: 2016 = 3.108 (2) - 2016=3.257 (5)
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