Small heat shock proteins: multifaceted proteins with important implications for life

Serena Carra , Simon Alberti , Justin L. P. Benesch , Wilbert Boelens , Johannes Buchner , John A. Carver , Ciro Cecconi , Heath Ecroyd , Nikolai Gusev , Lawrence E. Hightower , Rachel E. Klevit , Hyun O. Lee , Krzysztof Liberek , Brent Lockwood , Angelo Poletti , Vincent Timmerman , Melinda E. Toth , Elizabeth Vierling , Tangchun Wu , Robert M. Tanguay


Small Heat Shock Proteins (sHSPs) evolved early in the history of life; they are present in archaea, bacteria, and eukaryota. sHSPs belong to the superfamily of molecular chaperones: they are components of the cellular protein quality control machinery and are thought to act as the first line of defense against conditions that endanger the cellular proteome. In plants, sHSPs protect cells against abiotic stresses, providing innovative targets for sustainable agricultural production. In humans, sHSPs (also known as HSPBs) are associated with the development of several neurological diseases. Thus, manipulation of sHSP expression may represent an attractive therapeutic strategy for disease treatment. Experimental evidence demonstrates that enhancing the chaperone function of sHSPs protects against age-related protein conformation diseases, which are characterized by protein aggregation. Moreover, sHSPs can promote longevity and healthy aging in vivo. In addition, sHSPs have been implicated in the prognosis of several types of cancer. Here, sHSP upregulation, by enhancing cellular health, could promote cancer development; on the other hand, their downregulation, by sensitizing cells to external stressors and chemotherapeutics, may have beneficial outcomes. The complexity and diversity of sHSP function and properties and the need to identify their specific clients, as well as their implication in human disease, have been discussed by many of the world’s experts in the sHSP field during a dedicated workshop in Québec City, Canada, on 26–29 August 2018.
Author Serena Carra
Serena Carra,,
, Simon Alberti
Simon Alberti,,
, Justin L. P. Benesch
Justin L. P. Benesch,,
, Wilbert Boelens
Wilbert Boelens,,
, Johannes Buchner
Johannes Buchner,,
, John A. Carver
John A. Carver,,
, Ciro Cecconi
Ciro Cecconi,,
, Heath Ecroyd
Heath Ecroyd,,
, Nikolai Gusev
Nikolai Gusev,,
, Lawrence E. Hightower
Lawrence E. Hightower,,
et al.`
Journal seriesCell Stress & Chaperones, ISSN 1355-8145, (N/A 70 pkt)
Issue year2019
Publication size in sheets0.65
Keywords in Englishsmall Heat Shock Proteins, protein quality control, human diseases, plant biology
ASJC Classification1307 Cell Biology; 1303 Biochemistry
Languageen angielski
Score (nominal)70
Score sourcejournalList
ScoreMinisterial score = 70.0, 11-12-2019, ArticleFromJournal
Publication indicators WoS Citations = 3; Scopus SNIP (Source Normalised Impact per Paper): 2018 = 0.888; WoS Impact Factor: 2018 = 2.903 (2) - 2018=2.944 (5)
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