Production and biomedical application of flavivirus-like particles
Ewelina Król , Gabriela Brzuska , Bogusław Szewczyk
AbstractMany viruses belonging to the Flaviviridae family are transmitted by invertebrate vectors. Among those transmitted by mosquitos, there are many human pathogens of great medical importance, such as Japanese encephalitis virus, West Nile virus, dengue virus, Zika virus, or yellow fever virus. Millions of people contract mosquito-borne diseases each year, leading to thousands of deaths. Co-circulation of genetically similar flaviviruses in the same areas result in the generation of crossreactive antibodies, which is of serious concern for the development of effective vaccines and diagnostic tests. This review provides comprehensive insight into the potential use of virus-like particles as safe and effective antigens in both diagnostics tests, as well as in the development of vaccines against several mosquito-borne flaviviruses.
|Journal series||Trends in Biotechnology, ISSN 0167-7799, (N/A 200 pkt)|
|Publication size in sheets||0.7|
|Keywords in English||virus-like particles, flaviviruses, mosquito-borne viruses, vaccines, diagnosis|
|License||Other; published final; ; with publication|
|Score||= 200.0, 28-01-2020, ArticleFromJournal|
|Publication indicators||= 0; : 2016 = 3.143; : 2018 = 13.747 (2) - 2018=15.219 (5)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.