Production and biomedical application of flavivirus-like particles

Ewelina Król , Gabriela Brzuska , Bogusław Szewczyk

Abstract

Many viruses belonging to the Flaviviridae family are transmitted by invertebrate vectors. Among those transmitted by mosquitos, there are many human pathogens of great medical importance, such as Japanese encephalitis virus, West Nile virus, dengue virus, Zika virus, or yellow fever virus. Millions of people contract mosquito-borne diseases each year, leading to thousands of deaths. Co-circulation of genetically similar flaviviruses in the same areas result in the generation of crossreactive antibodies, which is of serious concern for the development of effective vaccines and diagnostic tests. This review provides comprehensive insight into the potential use of virus-like particles as safe and effective antigens in both diagnostics tests, as well as in the development of vaccines against several mosquito-borne flaviviruses.
Publication typeIn press (online first, early view)
Author Ewelina Król (IFB / IB / LRV)
Ewelina Król,,
- Laboratory of Recombinant Vaccines
, Gabriela Brzuska (IFB)
Gabriela Brzuska,,
- Intercollegiate Faculty of Biotechnology UG
, Bogusław Szewczyk (IFB / IB / LRV)
Bogusław Szewczyk,,
- Laboratory of Recombinant Vaccines
Journal seriesTrends in Biotechnology, ISSN 0167-7799, (A 45 pkt)
Issue year2019
Noonline first
Pages1-15
Publication size in sheets0.7
Keywords in Englishvirus-like particles, flaviviruses, mosquito-borne viruses, vaccines, diagnosis
ASJC Classification1502 Bioengineering; 1305 Biotechnology
DOIDOI:10.1016/j.tibtech.2019.03.013
URL https://doi.org/10.1016/j.tibtech.2019.03.013
Languageen angielski
LicenseOther; published final; Uznanie Autorstwa (CC-BY); with publication
Score (nominal)45
ScoreMinisterial score = 45.0, 24-07-2019, ArticleFromJournal
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2016 = 3.143; WoS Impact Factor: 2017 = 13.578 (2) - 2017=14.635 (5)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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