Mast cells in mastocytosis and allergy - important player in metabolic and immunological homeostasis

Joanna Renke , Sabina Kędzierska-Mieszkowska , Magdalena Lange , Bogusław Nedoszytko , Eliza Wasilewska , Anna Liberek , Marcin Renke , Marek Niedoszytko , Jacek Witkowski , Joanna Skórko-Glonek , Barbara Lipińska


The role of mast cell (MC) activity in pathophysiology is complex and challenging and its clinical effects are difficult to predict. Apart from the known role of MCs in basic immunological processes and allergy, underlined is their importance in bone mineralization and in regulation of autoimmune reactions. Mast cell mediators, especially those released from mast cells in degranulation, but also those released constitutively, are important both in metabolic and immunological processes. Mastocytosis is a heterogeneous group of disorders characterized by accumulation of MC in one or more organs. There are scientific data indicating that mastocytosis patients are at increased risk of osteoporosis in the systemic form of the disease and children with cutaneous mastocytosis have a higher rate of hypogammaglobulinemia. Moreover, the origin of osteoporosis in patients with allergy is no longer considered as linked to steroid therapy only, but to the mast cell mediators’ activity as well. There are indications that osteoporosis symptoms in this group of patients may develop independently of the cumulative steroids’ dose. Thus, the influence of mast cells on metabolic and immunologic processes in allergic patients should be investigated. The assessment of mast cell activity and burden in mastocytosis may be used to guide clinical management of patients with allergy.
Author Joanna Renke (FB / DB)
Joanna Renke,,
- Department of Biochemistry
, Sabina Kędzierska-Mieszkowska (FB / DB)
Sabina Kędzierska-Mieszkowska,,
- Department of Biochemistry
, Magdalena Lange - [Gdanski Uniwersytet Medyczny]
Magdalena Lange,,
- Gdanski Uniwersytet Medyczny
, Bogusław Nedoszytko - [Gdanski Uniwersytet Medyczny]
Bogusław Nedoszytko,,
- Gdanski Uniwersytet Medyczny
, Eliza Wasilewska - [Gdanski Uniwersytet Medyczny]
Eliza Wasilewska,,
- Gdanski Uniwersytet Medyczny
, Anna Liberek - [Gdanski Uniwersytet Medyczny]
Anna Liberek,,
- Gdanski Uniwersytet Medyczny
, Marcin Renke - [Gdanski Uniwersytet Medyczny]
Marcin Renke,,
- Gdanski Uniwersytet Medyczny
, Marek Niedoszytko - [Gdanski Uniwersytet Medyczny]
Marek Niedoszytko,,
- Gdanski Uniwersytet Medyczny
, Jacek Witkowski - [Gdanski Uniwersytet Medyczny]
Jacek Witkowski,,
- Gdanski Uniwersytet Medyczny
, Joanna Skórko-Glonek (FB / DB)
Joanna Skórko-Glonek,,
- Department of Biochemistry
et al.`
Journal seriesAdvances in Medical Sciences, ISSN 1896-1126, (N/A 100 pkt)
Issue year2019
Publication size in sheets0.5
Keywords in Englishmast cells, mastocytosis, allergy, osteoporosis, immunocompetence
ASJC Classification2700 General Medicine
Languageen angielski
Score (nominal)100
Score sourcejournalList
ScoreMinisterial score = 100.0, 29-05-2020, ArticleFromJournal
Publication indicators WoS Citations = 1; Scopus Citations = 5; Scopus SNIP (Source Normalised Impact per Paper): 2018 = 0.742; WoS Impact Factor: 2018 = 2.08 (2) - 2018=1.665 (5)
Citation count*5 (2020-05-30)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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