Mast cells in mastocytosis and allergy - important player in metabolic and immunological homeostasis

Joanna Renke , Sabina Kędzierska-Mieszkowska , Magdalena Lange , Bogusław Nedoszytko , Eliza Wasilewska , Anna Liberek , Marcin Renke , Marek Niedoszytko , Jacek Witkowski , Joanna Skórko-Glonek , Barbara Lipińska

Abstract

The role of mast cell (MC) activity in pathophysiology is complex and challenging and its clinical effects are difficult to predict. Apart from the known role of MCs in basic immunological processes and allergy, underlined is their importance in bone mineralization and in regulation of autoimmune reactions. Mast cell mediators, especially those released from mast cells in degranulation, but also those released constitutively, are important both in metabolic and immunological processes. Mastocytosis is a heterogeneous group of disorders characterized by accumulation of MC in one or more organs. There are scientific data indicating that mastocytosis patients are at increased risk of osteoporosis in the systemic form of the disease and children with cutaneous mastocytosis have a higher rate of hypogammaglobulinemia. Moreover, the origin of osteoporosis in patients with allergy is no longer considered as linked to steroid therapy only, but to the mast cell mediators’ activity as well. There are indications that osteoporosis symptoms in this group of patients may develop independently of the cumulative steroids’ dose. Thus, the influence of mast cells on metabolic and immunologic processes in allergic patients should be investigated. The assessment of mast cell activity and burden in mastocytosis may be used to guide clinical management of patients with allergy.
Author Joanna Renke (FB / DB)
Joanna Renke,,
- Department of Biochemistry
, Sabina Kędzierska-Mieszkowska (FB / DB)
Sabina Kędzierska-Mieszkowska,,
- Department of Biochemistry
, Magdalena Lange
Magdalena Lange,,
-
, Bogusław Nedoszytko
Bogusław Nedoszytko,,
-
, Eliza Wasilewska
Eliza Wasilewska,,
-
, Anna Liberek
Anna Liberek,,
-
, Marcin Renke
Marcin Renke,,
-
, Marek Niedoszytko
Marek Niedoszytko,,
-
, Jacek Witkowski
Jacek Witkowski,,
-
, Joanna Skórko-Glonek (FB / DB)
Joanna Skórko-Glonek,,
- Department of Biochemistry
et al.`
Journal seriesAdvances in Medical Sciences, ISSN 1896-1126, (A 15 pkt)
Issue year2019
Vol64
No1
Pages124-130
Publication size in sheets0.5
Keywords in Englishmast cells, mastocytosis, allergy, osteoporosis, immunocompetence
DOIDOI:10.1016/j.advms.2018.08.013
URL https://doi.org/10.1016/j.advms.2018.08.013
Languageen angielski
Score (nominal)15
ScoreMinisterial score = 15.0, 29-01-2019, ArticleFromJournal
Ministerial score (2013-2016) = 15.0, 29-01-2019, ArticleFromJournal
Publication indicators WoS Impact Factor: 2017 = 2.064 (2) - 2017=1.681 (5)
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