Transport of paracetamol in swellable and relaxing polyurethane nanocomposite hydrogels

Marta Miotke , Justyna Strankowska , Jerzy Kwela , Michał Strankowski , Marek Józefowicz

Abstract

Polyurethane hydrogels are potentially attractive materials for biomedical applications. They are able to absorb large amount of water, biological fluids or active substances, and thus, they have potential to be used as absorbents or wound-healing dressings. They are also used for the controlled release of therapeutics because of their capacity to embed biologically active agents in their water-swollen network. The presence of organofillized montmorillonite (Cloisite® 30B) in polyurethane nanocomposite hydrogels remarkably improves the swelling capability, but on the other hand slows down the release process of an active substance from the matrix. The swelling of paracetamol solution by the nanocomposite matrix and the release process of this active substance from the hydrogel were investigated using gravimetric analysis and spectroscopic method. The kinetics of both these processes were accurately analyzed by the use of Korsmeyer–Peppas and modified Hopfenberg and Weibull models. In the present paper, three different nanocomposite systems with various amounts of Cloisite® 30B were studied. The results of these studies confirm beneficial impact of the nanosize effect on the drug diffusion processes in polyurethane nanocomposite hydrogels.
Publication typeIn press (online first, early view)
Author Marta Miotke (FMPI / IEP)
Marta Miotke ,,
- Institute of Experimental Physics
, Justyna Strankowska (FMPI / IEP)
Justyna Strankowska,,
- Institute of Experimental Physics
, Jerzy Kwela (FMPI / IEP)
Jerzy Kwela,,
- Institute of Experimental Physics
, Michał Strankowski
Michał Strankowski,,
-
, Marek Józefowicz (FMPI / IEP)
Marek Józefowicz,,
- Institute of Experimental Physics
Journal seriesPolymer Bulletin, ISSN 0170-0839, (A 25 pkt)
Issue year2019
Noonline first
Pages1-17
Publication size in sheets0.8
ASJC Classification2505 Materials Chemistry; 2507 Polymers and Plastics; 3104 Condensed Matter Physics; 1600 General Chemistry
DOIDOI:10.1007/s00289-019-02755-6
URL https://link.springer.com/article/10.1007%2Fs00289-019-02755-6
Languageen angielski
LicenseOther; published final; Uznanie Autorstwa (CC-BY); with publication
Score (nominal)25
ScoreMinisterial score = 25.0, 24-07-2019, ArticleFromJournal
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2017 = 0.675; WoS Impact Factor: 2017 = 1.589 (2) - 2017=1.507 (5)
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