Selected nucleos(t)ide-based prescribed drugs and their multi-target activity
Gabriela Pastuch-Gawołek , Danuta Gillner , Ewelina Król , Krzysztof Walczak , Ilona Wandzik
AbstractNucleos(t)ide analogues play pivotal roles as antiviral, cytotoxic or immunosuppressive agents. Here, we review recent reports of nucleoside analogues that exhibit broad-spectrum activity towards multiple life-threatening RNA and DNA viruses. We also present a discussion about nucleoside antimetabolites—approved antineoplastic agents—that have recently been shown to have antiviral and/or antibacterial activity. The approved drugs and drug combinations, as well as recently identified candidates for investigation and/or experimentation, are discussed. Several examples of repurposed drugs that have already been approved for use are presented. This strategy can be crucial for the first-line treatment of acute infections or coinfections and for the management of drug-resistant strains.
|Journal series||European Journal of Pharmacology, ISSN 0014-2999, e-ISSN 1879-0712, (N/A 100 pkt)|
|Keywords in English||nucleosides, nucleotides, prodrugs, antiviral therapy, chain termination, antineoplastic agents|
|License||Other; published final; ; with publication|
|Score||= 100.0, 05-03-2020, ArticleFromJournal|
|Publication indicators||= 0.000; : 2018 = 0.958; : 2018 = 3.170 (2) - 2018=3.120 (5)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.