Selected nucleos(t)ide-based prescribed drugs and their multi-target activity

Gabriela Pastuch-Gawołek , Danuta Gillner , Ewelina Król , Krzysztof Walczak , Ilona Wandzik

Abstract

Nucleos(t)ide analogues play pivotal roles as antiviral, cytotoxic or immunosuppressive agents. Here, we review recent reports of nucleoside analogues that exhibit broad-spectrum activity towards multiple life-threatening RNA and DNA viruses. We also present a discussion about nucleoside antimetabolites—approved antineoplastic agents—that have recently been shown to have antiviral and/or antibacterial activity. The approved drugs and drug combinations, as well as recently identified candidates for investigation and/or experimentation, are discussed. Several examples of repurposed drugs that have already been approved for use are presented. This strategy can be crucial for the first-line treatment of acute infections or coinfections and for the management of drug-resistant strains.
Author Gabriela Pastuch-Gawołek
Gabriela Pastuch-Gawołek,,
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, Danuta Gillner
Danuta Gillner,,
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, Ewelina Król (IFB/IB/LRV)
Ewelina Król,,
- Laboratory of Recombinant Vaccines
, Krzysztof Walczak
Krzysztof Walczak,,
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, Ilona Wandzik
Ilona Wandzik,,
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Journal seriesEuropean Journal of Pharmacology, ISSN 0014-2999, e-ISSN 1879-0712, (N/A 100 pkt)
Issue year2019
Vol865
Pages1-13
Article number172747
Keywords in Englishnucleosides, nucleotides, prodrugs, antiviral therapy, chain termination, antineoplastic agents
ASJC Classification3004 Pharmacology
DOIDOI:10.1016/j.ejphar.2019.172747
URL https://www.sciencedirect.com/science/article/pii/S0014299919306995/pdfft?md5=b0f9b1ad7730f554ec0e61ad6389dddd&pid=1-s2.0-S0014299919306995-main.pdf
Languageen angielski
LicenseOther; published final; Uznanie Autorstwa (CC-BY); with publication
Score (nominal)100
Score sourcejournalList
ScoreMinisterial score = 100.0, 05-03-2020, ArticleFromJournal
Publication indicators WoS Citations = 0.000; Scopus SNIP (Source Normalised Impact per Paper): 2018 = 0.958; WoS Impact Factor: 2018 = 3.170 (2) - 2018=3.120 (5)
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