Potential contribution of monounsaturated fatty acids to cardiovascular risk in chronic kidney disease

Adriana Mika , Małgorzata Sikorska-Wiśniewska , Sylwia Małgorzewicz , Piotr Stepnowski , Alicja Dębska-Ślizień , Tomasz Śledziński , Michał Chmielewski


Introduction: Patients with chronic kidney disease (CKD) are particularly susceptible to cardiovascular disease (CVD). Increased synthesis of endogenous monounsaturated fatty acids (MUFAs) by stearoyl‑CoA desaturase‑1 (SCD1) might predispose to cardiovascular complications. Objectives: The aim of this study was to examine the serum MUFA content in patients at subsequent stages of CKD, and to evaluate associations between MUFA content and SCD1 activity, patients’ diet, and cardiovascular risk. Patients and methods: Serum fatty acid composition was evaluated in 177 patients with subsequent stages of CKD (1–2, 3a, 3b, 4–5, hemodialysis, peritoneal dialysis, and after kidney transplantation), and in 30 healthy controls. Gas chromatography–mass spectrometry was used for the measurement. Results: Serum MUFA content was shown to increase with subsequent stages of CKD and to be correlated with various risk factors of CVD, including serum triacylglycerols, HDL cholesterol (P <0.01), and high-sensitivity C-reactive protein (P <0.05). Moreover, also the prevalence of CVD was shown to increase with CKD progression. Estimated SCD1 activity was associated with serum MUFA content (P <0.01), but no association was found between dietary MUFA intake and serum MUFA levels. Conclusions: Our results indicate that the elevation of serum MUFA levels in CKD patients may contribute to an increased risk of CVD during CKD progression, mainly due to increased endogenous MUFA synthesis by SCD1.
Author Adriana Mika (FCh / DEA / LChER)
Adriana Mika,,
- Laboratory of Chemical Environmental Risks
, Małgorzata Sikorska-Wiśniewska
Małgorzata Sikorska-Wiśniewska,,
, Sylwia Małgorzewicz
Sylwia Małgorzewicz,,
, Piotr Stepnowski (FCh / DEA / LChER)
Piotr Stepnowski,,
- Laboratory of Chemical Environmental Risks
, Alicja Dębska-Ślizień
Alicja Dębska-Ślizień,,
, Tomasz Śledziński
Tomasz Śledziński,,
, Michał Chmielewski
Michał Chmielewski,,
Journal seriesPolskie Archiwum Medycyny Wewnętrznej, ISSN 0032-3772, (A 30 pkt)
Issue year2018
Publication size in sheets0.5
Keywords in Englishdyslipidemia, fatty acid desaturation, gas chromatography–mass spectrometry, lipid metabolism, triacylglycerols
ASJC Classification2724 Internal Medicine
URL http://dx.doi.org/10.20452/pamw.4376
Languageen angielski
LicenseOther; published final; Uznanie Autorstwa - Użycie Niekomercyjne - Na tych samych warunkach (CC-BY-NC-SA); with publication
Score (nominal)30
ScoreMinisterial score = 30.0, 30-09-2019, ArticleFromJournal
Publication indicators WoS Citations = 1; Scopus SNIP (Source Normalised Impact per Paper): 2017 = 0.611; WoS Impact Factor: 2017 = 2.658 (2) - 2017=1.894 (5)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.