In pursuit of key features for constructing electrochemical biosensors – electrochemical and acid-base characteristic of self-assembled monolayers on gold

Tomasz Swebocki , Paweł Niedziałkowski , Anna Cirocka , Elżbieta Szczepańska , Tadeusz Ossowski , Anna Wcisło

Abstract

Electrochemical biosensors are a well-known group of tools used widely in a variety of industries. Due to interactions between analytes and a surface, a measurable signal occurs which can then be processed to quantitative and/or qualitative data. The knowledge of surfaces’ electrochemical properties as well as their pKa is of great importance when it comes to the construction of biosensors based on an electrochemical signal. In our work, we focused on determining electrochemical properties as well as pKa of thiol-based SAMs – commonly used linker layers in biosensors. By applying cyclic voltammetry and electrochemical spectroscopy we were able to describe the overall resistive behaviour of SAMs synthesised with both alkanethiols and thiols with carboxyl and amine groups. Coherent use of contact angle measurements let us also describe the overall polarity of the investigated surfaces. The obtained data of pKa values differed from the ones described for bulk solutions of modifying agents, which yields important information for further modification of the surface.
Publication typeIn press (online first, early view)
Author Tomasz Swebocki (FCh/DACh/LSCh)
Tomasz Swebocki,,
- Laboratory of Supramolecular Chemistry
, Paweł Niedziałkowski (FCh/DACh/LSCh)
Paweł Niedziałkowski,,
- Laboratory of Supramolecular Chemistry
, Anna Cirocka (FCh/DACh/LSCh)
Anna Cirocka,,
- Laboratory of Supramolecular Chemistry
, Elżbieta Szczepańska (FCh/DACh/LChAC)
Elżbieta Szczepańska,,
- Laboratory of chemistry and Analytics of Cosmetics
, Tadeusz Ossowski (FCh/DACh/LSCh)
Tadeusz Ossowski,,
- Laboratory of Supramolecular Chemistry
, Anna Wcisło (FCh/DACh/LSCh)
Anna Wcisło,,
- Laboratory of Supramolecular Chemistry
Journal seriesSupramolecular Chemistry, ISSN 1061-0278, e-ISSN 1029-0478, (N/A 40 pkt)
Issue year2020
Noonline first
Pages1-11
Publication size in sheets0.50
Keywords in EnglishSurface pKa, self-assembled monolayer, gold, electrochemistry, contact angle
ASJC Classification1600 General Chemistry
DOIDOI:10.1080/10610278.2020.1739685
Languageen angielski
Score (nominal)40
Score sourcejournalList
ScoreMinisterial score = 40.0, 03-04-2020, ArticleFromJournal
Publication indicators WoS Citations = 0.000; Scopus SNIP (Source Normalised Impact per Paper): 2016 = 0.374; WoS Impact Factor: 2018 = 1.660 (2) - 2018=1.313 (5)
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