In pursuit of key features for constructing electrochemical biosensors – electrochemical and acid-base characteristic of self-assembled monolayers on gold
Tomasz Swebocki , Paweł Niedziałkowski , Anna Cirocka , Elżbieta Szczepańska , Tadeusz Ossowski , Anna Wcisło
AbstractElectrochemical biosensors are a well-known group of tools used widely in a variety of industries. Due to interactions between analytes and a surface, a measurable signal occurs which can then be processed to quantitative and/or qualitative data. The knowledge of surfaces’ electrochemical properties as well as their pKa is of great importance when it comes to the construction of biosensors based on an electrochemical signal. In our work, we focused on determining electrochemical properties as well as pKa of thiol-based SAMs – commonly used linker layers in biosensors. By applying cyclic voltammetry and electrochemical spectroscopy we were able to describe the overall resistive behaviour of SAMs synthesised with both alkanethiols and thiols with carboxyl and amine groups. Coherent use of contact angle measurements let us also describe the overall polarity of the investigated surfaces. The obtained data of pKa values differed from the ones described for bulk solutions of modifying agents, which yields important information for further modification of the surface.
|Journal series||Supramolecular Chemistry, ISSN 1061-0278, e-ISSN 1029-0478, (N/A 40 pkt)|
|Publication size in sheets||0.50|
|Keywords in English||Surface pKa, self-assembled monolayer, gold, electrochemistry, contact angle|
|Score||= 40.0, 03-04-2020, ArticleFromJournal|
|Publication indicators||= 0.000; : 2016 = 0.374; : 2018 = 1.660 (2) - 2018=1.313 (5)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.