Does C60 fullerene act as a transporter of small aromatic molecules?
Agnieszka Borowik , Yuriy Prylutskyy , Łukasz Kawelski , Olena Kyzyma , Leonid Bulavin , Oleksandr Ivankov , Vsevolod Cherepanov , Dariusz Wyrzykowski , Rajmund Kaźmierkiewicz , Grzegorz Gołuński , Anna Woziwodzka , Maxim Evstigneev , Uwe Ritter , Jacek Piosik
AbstractC60 fullerene is reported to directly interact with biomolecules, such as aromatic mutagens or anticancerdrugs. Therefore, it is extensively studied for its potential application in the fields of drug delivery andchemoprevention. Understanding the nature of fullerene-drugs interactions might contribute to opti-mization and modification of the existing chemotherapy systems. Possible interactions between ICR-191,a model acridine mutagen, with well-established biophysical properties and mutagenic activity, and C60fullerene aqueous solution were investigated by broad range of biophysical methods, such as DynamicLight Scattering, Isothermal Titration Calorimetry, and Atomic Force Microscopy. Additionally, to deter-mine biological activity of ICR-191-C60fullerene mixtures, Ames mutagenicity test was employed. It wasdemonstrated that C60fullerene interacts non-covalently with ICR-191 and has strong affinity to bacterialmembranes. The obtained results provide practical insight into C60fullerene interactions with aromaticcompounds.
|Journal series||Colloids and Surfaces B-Biointerfaces, ISSN 0927-7765, (A 35 pkt)|
|Publication size in sheets||0.5|
|Keywords in English||nanoparticles, direct interactions, nanocarriers, AFM|
|ASJC Classification||; ; ; ;|
|Score||= 35.0, 28-10-2019, ArticleFromJournal|
|Publication indicators||= 5; : 2017 = 1.101; : 2017 = 3.997 (2) - 2017=4.294 (5)|
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