Does C60 fullerene act as a transporter of small aromatic molecules?

Agnieszka Borowik , Yuriy Prylutskyy , Łukasz Kawelski , Olena Kyzyma , Leonid Bulavin , Oleksandr Ivankov , Vsevolod Cherepanov , Dariusz Wyrzykowski , Rajmund Kaźmierkiewicz , Grzegorz Gołuński , Anna Woziwodzka , Maxim Evstigneev , Uwe Ritter , Jacek Piosik


C60 fullerene is reported to directly interact with biomolecules, such as aromatic mutagens or anticancerdrugs. Therefore, it is extensively studied for its potential application in the fields of drug delivery andchemoprevention. Understanding the nature of fullerene-drugs interactions might contribute to opti-mization and modification of the existing chemotherapy systems. Possible interactions between ICR-191,a model acridine mutagen, with well-established biophysical properties and mutagenic activity, and C60fullerene aqueous solution were investigated by broad range of biophysical methods, such as DynamicLight Scattering, Isothermal Titration Calorimetry, and Atomic Force Microscopy. Additionally, to deter-mine biological activity of ICR-191-C60fullerene mixtures, Ames mutagenicity test was employed. It wasdemonstrated that C60fullerene interacts non-covalently with ICR-191 and has strong affinity to bacterialmembranes. The obtained results provide practical insight into C60fullerene interactions with aromaticcompounds.
Author Agnieszka Borowik (IFB)
Agnieszka Borowik,,
- Intercollegiate Faculty of Biotechnology UG
, Yuriy Prylutskyy
Yuriy Prylutskyy,,
, Łukasz Kawelski
Łukasz Kawelski,,
, Olena Kyzyma
Olena Kyzyma,,
, Leonid Bulavin
Leonid Bulavin,,
, Oleksandr Ivankov
Oleksandr Ivankov,,
, Vsevolod Cherepanov
Vsevolod Cherepanov,,
, Dariusz Wyrzykowski (FCh/DGICh/PBChN)
Dariusz Wyrzykowski,,
- Pracownia Biologicznej Chemii Nieorganicznej
, Rajmund Kaźmierkiewicz (IFB/IB/LBSS)
Rajmund Kaźmierkiewicz,,
- Laboratory of Biomolecular Systems Simulations
, Grzegorz Gołuński (IFB)
Grzegorz Gołuński,,
- Intercollegiate Faculty of Biotechnology UG
et al.`
Journal seriesColloids and Surfaces B-Biointerfaces, ISSN 0927-7765, (A 35 pkt)
Issue year2018
Publication size in sheets0.50
Keywords in Englishnanoparticles, direct interactions, nanocarriers, AFM
ASJC Classification1505 Colloid and Surface Chemistry; 1606 Physical and Theoretical Chemistry; 3110 Surfaces and Interfaces; 2700 General Medicine; 1305 Biotechnology
Languageen angielski
Score (nominal)35
Score sourcejournalList
ScoreMinisterial score = 35.0, 28-01-2020, ArticleFromJournal
Publication indicators WoS Citations = 5.000; Scopus SNIP (Source Normalised Impact per Paper): 2018 = 1.042; WoS Impact Factor: 2018 = 3.973 (2) - 2018=4.180 (5)
Citation count*12 (2020-04-21)
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