Are bilateral breast cancers and breast cancers coexisting with ovarian cancer different from solitary tumors? A pair-matched immunohistochemical analysis aimed at intrinsic tumor phenotype

Elżbieta Senkus , Jolanta Szade , Beata Pieczyńska , Anna Żaczek , Maciej Świerblewski , Wojciech Biernat , Jacek Jassem

Abstract

Patients with bilateral breast cancer (BBC) and breast‐ovarian cancer syndrome (BOCS) constitute populations potentially enriched for molecular defects involved in the pathomechanisms of these malignancies. The aim of our study was to compare tumor morphology and expression of estrogen and progesterone receptor, HER2, Ki67, cytokeratin 5/6, E‐cadherin, vimentin and epidermal growth factor receptor in tissue microarrays from 199 tumors from BBC or BOCS patients and 199 age‐matched solitary tumors. Compared to controls, BBC and BOCS considered jointly had lower incidence of DCIS, lower expression of PgR and HER2, and higher expression of Ki67 and vimentin. BOCS tumors were of higher grade, had lower expression of ER and PgR and higher expression of Ki67, CK5/6, vimentin and EGFR. BBC had less DCIS component, lower HER2 expression and higher Ki67 expression. Metachronous BBC (mBBC) had lower expression of ER, PgR and HER2, and higher expression of Ki67 and vimentin. Synchronous BBC (sBBC) had less DCIS component, higher expression of ER, and lower expression of CK5/6, EGFR and E‐cadherin. BBC and breast cancers in BOCS differ in many aspects from solitary tumors. BBC are a heterogeneous group of tumors, differing between sBBC and mBBC. mBBC phenotype shares many features with BOCS tumors.
Author Elżbieta Senkus
Elżbieta Senkus,,
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, Jolanta Szade
Jolanta Szade,,
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, Beata Pieczyńska
Beata Pieczyńska,,
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, Anna Żaczek KBM
Anna Żaczek,,
- Department of Medical Biotechnology
, Maciej Świerblewski
Maciej Świerblewski,,
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, Wojciech Biernat
Wojciech Biernat,,
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, Jacek Jassem
Jacek Jassem,,
-
Journal seriesPathology International, ISSN 1320-5463
Issue year2014
Vol64
Pages508-517
Publication size in sheets0.5
Keywords in Englishbilateral breast cancer, breast-ovarian cancer syndrome, immunohistochemistry, intrinsic phenotype, tissue microarray
DOIDOI:10.1111/pin.12202
URL http://onlinelibrary.wiley.com/doi/10.1111/pin.12202/pdf
Languageen angielski
Score (nominal)25
ScoreMinisterial score = 20.0, 20-12-2017, ArticleFromJournal
Ministerial score (2013-2016) = 25.0, 20-12-2017, ArticleFromJournal
Publication indicators WoS Impact Factor: 2014 = 1.691 (2) - 2014=1.789 (5)
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