The role of TLRs in anti-cancer immunity and tumor rejection

Zuzanna Urban-Wójciuk , Mohd M. Khan , Benjamin L. Oyler , Robin Fahraeus , Natalia Marek-Trzonkowska , Aleksandra Nita-Lazar , Theodore Hupp , David Goodlett

Abstract

In recent years, a lot of scientific interest has focused on cancer immunotherapy. Although chronic inflammation has been described as one of the hallmarks of cancer, acute inflammation can actually trigger the immune system to fight diseases, including cancer. Toll-like receptor (TLR) ligands have long been used as adjuvants for traditional vaccines and it seems they may also play a role enhancing efficiency of tumor immunotherapy. The aim of this perspective is to discuss the effects of TLR stimulation in cancer, expression of various TLRs in different types of tumors, and finally the role of TLRs in anti-cancer immunity and tumor rejection.
Author Zuzanna Urban-Wójciuk (ICCVS)
Zuzanna Urban-Wójciuk,,
- International Centre for Cancer Vaccine Science
, Mohd M. Khan
Mohd M. Khan,,
-
, Benjamin L. Oyler
Benjamin L. Oyler,,
-
, Robin Fahraeus (ICCVS)
Robin Fahraeus,,
- International Centre for Cancer Vaccine Science
, Natalia Marek-Trzonkowska (ICCVS) - [Gdanski Uniwersytet Medyczny]
Natalia Marek-Trzonkowska,,
- International Centre for Cancer Vaccine Science
- Gdański Uniwersytet Medyczny
, Aleksandra Nita-Lazar
Aleksandra Nita-Lazar,,
-
, Theodore Hupp (ICCVS)
Theodore Hupp,,
- International Centre for Cancer Vaccine Science
, David Goodlett (ICCVS)
David Goodlett,,
- International Centre for Cancer Vaccine Science
Journal seriesFrontiers in Immunology, ISSN 1664-3224, (N/A 140 pkt)
Issue year2019
Vol10
Pages1-10
Publication size in sheets0.5
Article number2388
Keywords in Englishtoll-like receptors, immuno-oncology, anti-cancer immunity, tumor rejection, immunotherapy
ASJC Classification2723 Immunology and Allergy; 2403 Immunology
DOIDOI:10.3389/fimmu.2019.02388
URL https://doi.org/10.3389/fimmu.2019.02388
Languageen angielski
LicenseJournal (articles only); published final; Uznanie Autorstwa (CC-BY); with publication
Score (nominal)140
Score sourcejournalList
ScoreMinisterial score = 140.0, 25-02-2020, ArticleFromJournal
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2018 = 1.092; WoS Impact Factor: 2018 = 4.716 (2) - 2018=5.789 (5)
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