Adoptive cell therapy - harnessing antigen-specific T cells to target solid tumours
Elżbieta Chruściel , Zuzanna Urban-Wójciuk , Łukasz Arcimowicz , Małgorzata Kurkowiak , Jacek Kowalski , Mateusz Gliwiński , Tomasz Marjański , Witold Rzyman , Wojciech Biernat , Rafał Dziadziuszko , Carla Montesano , Roberta Bernardini , Natalia Marek-Trzonkowska
AbstractIn recent years, much research has been focused on the field of adoptive cell therapies (ACT) that use native or genetically modified T cells as therapeutic tools. Immunotherapy with T cells expressing chimeric antigen receptors (CARs) demonstrated great success in the treatment of haematologic malignancies, whereas adoptive transfer of autologous tumour infiltrating lymphocytes (TILs) proved to be highly effective in metastatic melanoma. These encouraging results initiated many studies where ACT was tested as a treatment for various solid tumours. In this review, we provide an overview of the challenges of T cell-based immunotherapies of solid tumours. We describe alternative approaches for choosing the most efficient T cells for cancer treatment in terms of their tumour-specificity and phenotype. Finally, we present strategies for improvement of anti-tumour potential of T cells, including combination therapies.
|Journal series||Cancers, ISSN 2072-6694, (N/A 140 pkt)|
|Publication size in sheets||1.45|
|Keywords in English||adoptive cell therapy of cancer, immunotherapy, TCR therapy, neoantigens, antigenspecific T cells, T cell-based therapy of solid tumours|
|License||Journal (articles only); published final; ; with publication|
|Score||= 140.0, 30-04-2020, ArticleFromJournal|
|Publication indicators||: 2018 = 1.440; : 2018 = 6.162 (2)|
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