Adoptive cell therapy - harnessing antigen-specific T cells to target solid tumours

Elżbieta Chruściel , Zuzanna Urban-Wójciuk , Łukasz Arcimowicz , Małgorzata Kurkowiak , Jacek Kowalski , Mateusz Gliwiński , Tomasz Marjański , Witold Rzyman , Wojciech Biernat , Rafał Dziadziuszko , Carla Montesano , Roberta Bernardini , Natalia Marek-Trzonkowska

Abstract

In recent years, much research has been focused on the field of adoptive cell therapies (ACT) that use native or genetically modified T cells as therapeutic tools. Immunotherapy with T cells expressing chimeric antigen receptors (CARs) demonstrated great success in the treatment of haematologic malignancies, whereas adoptive transfer of autologous tumour infiltrating lymphocytes (TILs) proved to be highly effective in metastatic melanoma. These encouraging results initiated many studies where ACT was tested as a treatment for various solid tumours. In this review, we provide an overview of the challenges of T cell-based immunotherapies of solid tumours. We describe alternative approaches for choosing the most efficient T cells for cancer treatment in terms of their tumour-specificity and phenotype. Finally, we present strategies for improvement of anti-tumour potential of T cells, including combination therapies.
Author Elżbieta Chruściel (ICCVS)
Elżbieta Chruściel,,
- International Centre for Cancer Vaccine Science
, Zuzanna Urban-Wójciuk (ICCVS)
Zuzanna Urban-Wójciuk,,
- International Centre for Cancer Vaccine Science
, Łukasz Arcimowicz (ICCVS)
Łukasz Arcimowicz,,
- International Centre for Cancer Vaccine Science
, Małgorzata Kurkowiak (ICCVS)
Małgorzata Kurkowiak,,
- International Centre for Cancer Vaccine Science
, Jacek Kowalski (ICCVS) - [Medical Uniwersity of Gdańsk (GUMed)]
Jacek Kowalski,,
- International Centre for Cancer Vaccine Science
- Gdański Uniwersytet Medyczny
, Mateusz Gliwiński
Mateusz Gliwiński,,
-
, Tomasz Marjański
Tomasz Marjański,,
-
, Witold Rzyman
Witold Rzyman,,
-
, Wojciech Biernat
Wojciech Biernat,,
-
, Rafał Dziadziuszko
Rafał Dziadziuszko,,
-
et al.`
Journal seriesCancers, ISSN 2072-6694, (N/A 140 pkt)
Issue year2020
Vol12
No3
Pages1-30
Publication size in sheets1.45
Article number683
Keywords in Englishadoptive cell therapy of cancer, immunotherapy, TCR therapy, neoantigens, antigenspecific T cells, T cell-based therapy of solid tumours
ASJC Classification2730 Oncology; 1306 Cancer Research
DOIDOI:10.3390/cancers12030683
URL https://doi.org/10.3390/cancers12030683
Languageen angielski
LicenseJournal (articles only); published final; Uznanie Autorstwa (CC-BY); with publication
Score (nominal)140
Score sourcejournalList
ScoreMinisterial score = 140.0, 30-04-2020, ArticleFromJournal
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2018 = 1.440; WoS Impact Factor: 2018 = 6.162 (2)
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