Characterization and influence of hydroxyapatite nanopowders on living cells

Przemyslaw Oberbek , Tomasz Bolek , Adrian Chlanda , Seishiro Hirano , Sylwia Kusnieruk , Julia Rogowska-Tylman , Ganna Nechyporenko , Viktor Zinchenko , Wojciech Swieszkowski , Tomasz Puzyn

Abstract

Nanomaterials, such as hydroxyapatite nanoparticles show a great promise for medical applications due to their unique properties at the nanoscale. However, there are concerns about the safety of using these materials in biological environments. Despite a great number of published studies of nanoobjects and their aggregates or agglomerates, the impact of their physicochemical properties (such as particle size, surface area, purity, details of structure and degree of agglomeration) on living cells is not yet fully understood. Significant differences in these properties, resulting from different manufacturing methods, are yet another problem to be taken into consideration. The aim of this work was to investigate the correlation between the properties of nanoscale hydroxyapatite from different synthesis methods and biological activity represented by the viability of four cell lines: A549, CHO, BEAS- 2B and J774.1 to assess the influence of the nanoparticles on immune, reproductive and respiratory systems.
Author Przemyslaw Oberbek
Przemyslaw Oberbek,,
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, Tomasz Bolek
Tomasz Bolek,,
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, Adrian Chlanda
Adrian Chlanda,,
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, Seishiro Hirano
Seishiro Hirano,,
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, Sylwia Kusnieruk
Sylwia Kusnieruk,,
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, Julia Rogowska-Tylman
Julia Rogowska-Tylman,,
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, Ganna Nechyporenko
Ganna Nechyporenko,,
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, Viktor Zinchenko
Viktor Zinchenko,,
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, Wojciech Swieszkowski
Wojciech Swieszkowski,,
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, Tomasz Puzyn (FCh / DEChR / LECh)
Tomasz Puzyn,,
- Laboratory of Environmental Chemometrics
Journal seriesBeilstein Journal of Nanotechnology, ISSN 2190-4286, (A 35 pkt)
Issue year2018
Vol9
Pages3079-3094
Publication size in sheets0.75
Keywords in Englishnanomaterials safety, biomaterials, tissue engineering, microscopic characterization, cytotoxicity, hydroxyapatite
ASJC Classification2208 Electrical and Electronic Engineering; 3100 General Physics and Astronomy; 2500 General Materials Science
DOIDOI:10.3762/bjnano.9.286
URL https://www.beilstein-journals.org/bjnano/content/pdf/2190-4286-9-286.pdf
Languageen angielski
LicenseJournal (articles only); published final; Uznanie Autorstwa (CC-BY); with publication
Score (nominal)35
ScoreMinisterial score = 35.0, 30-09-2019, ArticleFromJournal
Publication indicators WoS Citations = 0; Scopus SNIP (Source Normalised Impact per Paper): 2017 = 1.233; WoS Impact Factor: 2017 = 2.968 (2) - 2017=3.191 (5)
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