Characterization and influence of hydroxyapatite nanopowders on living cells
Przemyslaw Oberbek , Tomasz Bolek , Adrian Chlanda , Seishiro Hirano , Sylwia Kusnieruk , Julia Rogowska-Tylman , Ganna Nechyporenko , Viktor Zinchenko , Wojciech Swieszkowski , Tomasz Puzyn
AbstractNanomaterials, such as hydroxyapatite nanoparticles show a great promise for medical applications due to their unique properties at the nanoscale. However, there are concerns about the safety of using these materials in biological environments. Despite a great number of published studies of nanoobjects and their aggregates or agglomerates, the impact of their physicochemical properties (such as particle size, surface area, purity, details of structure and degree of agglomeration) on living cells is not yet fully understood. Significant differences in these properties, resulting from different manufacturing methods, are yet another problem to be taken into consideration. The aim of this work was to investigate the correlation between the properties of nanoscale hydroxyapatite from different synthesis methods and biological activity represented by the viability of four cell lines: A549, CHO, BEAS- 2B and J774.1 to assess the influence of the nanoparticles on immune, reproductive and respiratory systems.
|Journal series||Beilstein Journal of Nanotechnology, ISSN 2190-4286, (A 35 pkt)|
|Publication size in sheets||0.75|
|Keywords in English||nanomaterials safety, biomaterials, tissue engineering, microscopic characterization, cytotoxicity, hydroxyapatite|
|ASJC Classification||; ;|
|License||Journal (articles only); published final; ; with publication|
|Score|| = 30.0, 10-04-2019, ArticleFromJournal|
= 35.0, 10-04-2019, ArticleFromJournal
|Publication indicators||= 0; : 2017 = 1.233; : 2017 = 2.968 (2) - 2017=3.191 (5)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.