Matriptase-2: monitoring and inhibiting its proteolytic activity
Agata Gitlin-Domagalska , Martin Mangold , Dawid Dębowski , Natalia Ptaszyńska , Anna Łęgowska , Michael Gütschow , Krzysztof Rolka
AbstractMatriptase-2 (MT2) is a membrane-anchored proteolytic enzyme. It acts as the proteolytic key regulator in human iron homeostasis. A high expression level can lead to iron overload diseases, whereas mutations in the gene encoding MT2, TMPRSS6, may result in various forms of iron deficiency anemia. Recently, MT2 has been reported as a positive prognostic factor in breast and prostate cancers. However, the exact functions of MT2 in various pathophysiological conditions are still not fully understood. In this review, we describe the synthetic tools designed and synthesized to regulate or monitor MT2 proteolytic activity and present the latest knowledge about the role of MT2 in iron homeostasis and cancer.
|Journal series||Future Medicinal Chemistry, ISSN 1756-8919, (A 40 pkt)|
|Publication size in sheets||0.3|
|Keywords in English||anemia, fluorogenic substrates, hepcidin, iron overload, matriptase-2, peptide inhibitors, serine proteases|
|ASJC Classification||; ;|
|Score|| = 40.0, ArticleFromJournal|
= 40.0, ArticleFromJournal
|Publication indicators||= 0; : 2016 = 0.763; : 2017 = 3.969 (2) - 2017=3.973 (5)|
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