The leaching behavior of cyclophosphamide and ifosfamide from soil in the presence of co-contaminant: mixture sorption approach

Katarzyna Mioduszewska , Joanna Maszkowska , Anna Białk-Bielińska , Oliver Krüger , Ute Kalbe , Beata Liberek , Paulina Łukaszewicz , Piotr Stepnowski


Anticancer drugs (ACDs) exhibit high biological activity, they are cytotoxic, genotoxic, and are constantly released into the environment as a result of incomplete metabolism. Consequently they pose a serious threat to the environment and human health due to their carcinogenic, mutagenic and/or reproductive toxicity properties. Knowledge of their bioavailability, including their sorption to soils and their impact on the soil–groundwater pathway, is crucial for their risk assessment. Laboratory batch and column leaching tests are important tools for determining the release potential of contaminants from soil or waste material. Batch and column tests were carried out with soils differing in physicochemical properties, each spiked with cyclophosphamide (CK) or ifosfamide (IF). Moreover, due to the fact that environmental pollutants may occur as coexisting compounds in the soil the mobility evaluation for ACDs in the mixture with metoprolol (MET; β-blocker) as a co-contaminant was performed. In order to assess appropriateness, the batch and column tests were compared. The release depended on the properties of both the soil and the presence of co-contaminants. The faster release was observed for coarse-grained soil with the smallest organic matter content (MS soil: 90% decrease in concentration until liquid-to-solid ratio (L/S) of 0.3 L kg− 1 for all tests' layout) than for loamy sand (LS soil: 90% decrease in concentration until ratio L/S of 0.75 L kg− 1). ACDs are highly mobile in soil systems. Furthermore, the decrease of mobility of ifosfamide was observed with the presence of a co-contaminant (metoprolol) in both of the soils (in MS soil a decrease of 29%; in LS soil a decrease of 26%). The mobility of cyclophosphamide does not depend on the presence of a contaminant for MS soil, but also exhibits a decrease of 21% in LS soil.
Author Katarzyna Mioduszewska (FCh / DEA / LChER)
Katarzyna Mioduszewska,,
- Laboratory of Chemical Environmental Risks
, Joanna Maszkowska (FCh / DEA / LChER)
Joanna Maszkowska,,
- Laboratory of Chemical Environmental Risks
, Anna Białk-Bielińska (FCh / DEA / LChER)
Anna Białk-Bielińska,,
- Laboratory of Chemical Environmental Risks
, Oliver Krüger - [Federal Institute for Materials Research and Testing Berlin]
Oliver Krüger,,
- Federal Institute for Materials Research and Testing Berlin
, Ute Kalbe - [Federal Institute for Materials Research and Testing Berlin]
Ute Kalbe,,
- Federal Institute for Materials Research and Testing Berlin
, Beata Liberek (FCh / DOCh / LG)
Beata Liberek,,
- Laboratory of Glycochemistry
, Paulina Łukaszewicz (FCh / DEA / LChER)
Paulina Łukaszewicz,,
- Laboratory of Chemical Environmental Risks
, Piotr Stepnowski (FCh / DEA / LChER)
Piotr Stepnowski,,
- Laboratory of Chemical Environmental Risks
Journal seriesScience of the Total Environment, ISSN 0048-9697, (A 40 pkt)
Issue year2016
Publication size in sheets0.5
Keywords in Englishsorption, anticancer drugs, beta-blocker, metoprolol
Languageen angielski
Score (nominal)40
ScoreMinisterial score = 40.0, ArticleFromJournal
Ministerial score (2013-2016) = 40.0, ArticleFromJournal
Publication indicators Scopus Citations = 0; WoS Citations = 0; WoS Impact Factor: 2016 = 4.9 (2) - 2016=5.102 (5)
Citation count*1 (2019-10-16)
Share Share

Get link to the record

* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.