FGFs/FGFRs-dependent signalling in regulation of steroid hormone receptors – implications for therapy of luminal breast cancer

Dominika Piasecka , Marcin Braun , Kamila Kitowska , Kamil Mieczkowski , Radzislaw Kordek , Rafał Sądej , Hanna Romanska


Stromal stimuli mediated by growth factor receptors, leading to ligand-independent activation of steroid hormone receptors, have long been implicated in development of breast cancer resistance to endocrine therapy. Mutations in fibroblast growth factor receptor (FGFR) genes have been associated with a higher incidence and progression of breast cancer. Increasing evidence suggests that FGFR-mediated interaction between luminal invasive ductal breast carcinoma (IDC) and its microenvironment contributes to the progression to hormone-independence. Therapeutic strategies based on FGFR inhibitors hold promise for overcoming resistance to the ER-targeting treatment. A series of excellent reviews discuss a potential role of FGFR in development of IDC. Here, we provide a concise updated summary of existing literature on FGFR-mediated signalling with an emphasis on an interaction between FGFR and estrogen/progesterone receptors (ER/PR) in IDC. Focusing on the regulatory role of tumour microenvironment in the activity of steroid hormone receptors, we compile the available functional data on FGFRs-mediated signalling, as a fundamental mechanism of luminal IDC progression and failure of anti-ER treatment. We also highlight the translational value of the presented findings and summarize ongoing oncologic clinical trials investigating FGFRs inhibition in interventional studies in breast cancer.
Author Dominika Piasecka
Dominika Piasecka,,
, Marcin Braun
Marcin Braun,,
, Kamila Kitowska (IFB / DMedB)
Kamila Kitowska,,
- Department of Medical Biotechnology
, Kamil Mieczkowski (IFB)
Kamil Mieczkowski,,
- Intercollegiate Faculty of Biotechnology UG
, Radzislaw Kordek
Radzislaw Kordek,,
, Rafał Sądej (IFB / DMedB)
Rafał Sądej,,
- Department of Medical Biotechnology
, Hanna Romanska
Hanna Romanska,,
Journal seriesJournal of Experimental & Clinical Cancer Research, ISSN 1756-9966, (N/A 140 pkt)
Issue year2019
Publication size in sheets0.55
Article number230
Keywords in Englishbreast cancer, estrogen receptor, progesterone receptor, tumour microenvironment, fibroblast growth factor receptors
ASJC Classification2730 Oncology; 1306 Cancer Research
URL https://doi.org/10.1186/s13046-019-1236-6
Languageen angielski
LicenseJournal (articles only); published final; Uznanie Autorstwa (CC-BY); with publication
Score (nominal)140
Score sourcejournalList
ScoreMinisterial score = 140.0, 31-01-2020, ArticleFromJournal
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2018 = 1.277; WoS Impact Factor: 2018 = 5.646 (2) - 2018=5.14 (5)
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