FGFs/FGFRs-dependent signalling in regulation of steroid hormone receptors – implications for therapy of luminal breast cancer
Dominika Piasecka , Marcin Braun , Kamila Kitowska , Kamil Mieczkowski , Radzislaw Kordek , Rafał Sądej , Hanna Romanska
AbstractStromal stimuli mediated by growth factor receptors, leading to ligand-independent activation of steroid hormone receptors, have long been implicated in development of breast cancer resistance to endocrine therapy. Mutations in fibroblast growth factor receptor (FGFR) genes have been associated with a higher incidence and progression of breast cancer. Increasing evidence suggests that FGFR-mediated interaction between luminal invasive ductal breast carcinoma (IDC) and its microenvironment contributes to the progression to hormone-independence. Therapeutic strategies based on FGFR inhibitors hold promise for overcoming resistance to the ER-targeting treatment. A series of excellent reviews discuss a potential role of FGFR in development of IDC. Here, we provide a concise updated summary of existing literature on FGFR-mediated signalling with an emphasis on an interaction between FGFR and estrogen/progesterone receptors (ER/PR) in IDC. Focusing on the regulatory role of tumour microenvironment in the activity of steroid hormone receptors, we compile the available functional data on FGFRs-mediated signalling, as a fundamental mechanism of luminal IDC progression and failure of anti-ER treatment. We also highlight the translational value of the presented findings and summarize ongoing oncologic clinical trials investigating FGFRs inhibition in interventional studies in breast cancer.
|Journal series||Journal of Experimental & Clinical Cancer Research, ISSN 1756-9966, (N/A 140 pkt)|
|Publication size in sheets||0.55|
|Keywords in English||breast cancer, estrogen receptor, progesterone receptor, tumour microenvironment, fibroblast growth factor receptors|
|License||Journal (articles only); published final; ; with publication|
|Score||= 140.0, 31-01-2020, ArticleFromJournal|
|Publication indicators||: 2018 = 1.277; : 2018 = 5.646 (2) - 2018=5.14 (5)|
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