Cognitive predictors of cortical thickness in healthy aging

Patrycja Naumczyk , Angelika K. Sawicka , Beata Brzeska , Agnieszka Sabisz , Krzysztof Jodzio , Marek Radkowski , Karolina Czachowska , Paweł J. Winklewski , Karolina Finc , Edyta Szurowska , Urszula Demkow , Arkadiusz Szarmach

Abstract

This study seeks to define the role of predictive values of the motor speed, inhibition control, and fluid and crystallized intelligence in estimating the cortical thickness in healthy elderly. Forty-six older healthy subjects (37 women, 9 men) over 60 years of age were included in the study. The participants were examined on 3.0 T MRI scanners. The protocol included standard anatomical sequences, to exclude brain pathology, and a high-resolution T1-weighted sequence used to estimate the cortical thickness. The neuropsychological protocol included fluid intelligence assessment (Raven Progressive Matrices), crystalized intelligence assessment (information or vocabulary subtest of the Wechsler Adult Intelligence Scale-Revised (WAIS-R)), and executive functioning (Color Traits Test). The findings unraveled several interdependencies. The higher the intelligence, the thicker was the grey matter in nine regions of both hemispheres, but also some paradoxical reversed associations were found in four areas; all of them were localized along different sections of the cingulate gyrus in both hemispheres. An inverse association was found between crystallized intelligence and the thickness of the pars opecularis of the right hemisphere. The better the executive functioning, the thicker was the grey matter of a given region. The better the motor performance, the thicker was the grey matter of the rostral middle frontal area of the left hemisphere and the lingual gyrus of both hemispheres. In conclusion, the associations unraveled demonstrate that the neural mechanisms underlying healthy aging are complex and heterogenic across different cognitive domains and neuroanatomical regions. No brain aging theory seems to provide a suitable interpretative framework for all the results. A novel, more integrative approach to the brain aging should be considered.
Publication typeIn press (online first, early view)
Author Patrycja Naumczyk (FSS / IPsych / DGPsych)
Patrycja Naumczyk,,
- Division of General Psychology
, Angelika K. Sawicka
Angelika K. Sawicka,,
-
, Beata Brzeska
Beata Brzeska,,
-
, Agnieszka Sabisz
Agnieszka Sabisz,,
-
, Krzysztof Jodzio (FSS / IPsych / DGPsych)
Krzysztof Jodzio,,
- Division of General Psychology
, Marek Radkowski
Marek Radkowski,,
-
, Karolina Czachowska
Karolina Czachowska,,
-
, Paweł J. Winklewski
Paweł J. Winklewski,,
-
, Karolina Finc
Karolina Finc,,
-
, Edyta Szurowska
Edyta Szurowska,,
-
et al.`
Journal seriesAdvances in Experimental Medicine and Biology, ISSN 0065-2598, (A 25 pkt)
Issue year2018
Pages1-12
Publication size in sheets0.55
Keywords in Englishaging process, cortical thickness, grey matter, healthy aging, inhibition control, intelligence, motor speed
DOIDOI:10.1007/5584_2018_265
URL https://link.springer.com/content/pdf/10.1007%2F5584_2018_265.pdf
Languageen angielski
Score (nominal)25
ScoreMinisterial score = 25.0, 02-10-2018, ArticleFromJournal
Ministerial score (2013-2016) = 25.0, 02-10-2018, ArticleFromJournal
Publication indicators WoS Impact Factor: 2016 = 1.937 (2) - 2016=1.765 (5)
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