Influence of primary ligands (ODA, TDA) on physicochemical and biological properties of oxidovanadium (IV) complexes with bipy and phen as auxiliary ligands

Joanna Pranczk , Aleksandra Tesmar , Dariusz Wyrzykowski , Iwona Inkielewicz-Stępniak , Dagmara Jacewicz , Lech Chmurzyński

Abstract

The influence of the oxydiacetate (ODA) and thiodiacetate (TDA) ligands on the physicochemical and biological properties of the oxidovanadium(IV) ternary complexes of the VO(L)(B) type, where L denotes ODA or TDA and B denotes 2,2′-bipyridine (bipy) or 1,10-phenanthroline (phen), has been investigated. The stability of the complexes in aqueous solutions, assessed based on the potentiometric titration method, increases in the following direction: VO(TDA)(bipy) < VO(ODA)(bipy) < VO(TDA)(phen) < VO(ODA)(phen). Furthermore, the influence of the TDA and ODA ligands on the antioxidant activity of the oxidovanadium(IV) complexes toward superoxide free radical (O2 •−), 2,2′-azinobis(3-ethylbenzothiazoline-6 sulfonic acid) cation radical (ABTS+•) and 2,2-diphenyl-1-picrylhydrazyl radical (DPPH•) has been examined and discussed. The reactivity of the complexes toward O2 •− increases in the following direction: VO(TDA)(phen) < VO(TDA)(bipy) ≈ VO(ODA)(bipy) < VO(ODA)(phen). The antioxidant activity against ABTS+• and DPPH• free radicals is higher for phen complexes, whereas the thiodiacetate complexes are more reactive than are the corresponding oxydiacetate ones. Finally, herein, the cytoprotective activity of the complexes against the oxidative damage generated exogenously by hydrogen peroxide in the hippocampal neuronal HT22 cell line (the MTT and LDH tests) is reported. In a low concentration (1 μM), the cytoprotective action of thiodiacetate complexes is much higher than that of the corresponding oxydiacetate complexes. However, in the higher concentration range (10 and 100 μM), the antioxidant activity of the complexes is overcompensated by their cytotoxic effect.
Author Joanna Pranczk (FCh / DGICh / LPCC)
Joanna Pranczk,,
- Laboratory of Physicochemistry of Coordination Complexes
, Aleksandra Tesmar (FCh / DGICh / LPCC)
Aleksandra Tesmar,,
- Laboratory of Physicochemistry of Coordination Complexes
, Dariusz Wyrzykowski (FCh / DGICh / LPCC)
Dariusz Wyrzykowski,,
- Laboratory of Physicochemistry of Coordination Complexes
, Iwona Inkielewicz-Stępniak
Iwona Inkielewicz-Stępniak,,
-
, Dagmara Jacewicz (FCh / DGICh / LPCC)
Dagmara Jacewicz,,
- Laboratory of Physicochemistry of Coordination Complexes
, Lech Chmurzyński (FCh / DGICh / LPCC)
Lech Chmurzyński,,
- Laboratory of Physicochemistry of Coordination Complexes
Journal seriesBiological Trace Element Research, ISSN 0163-4984, (A 15 pkt)
Issue year2016
Vol174
No1
Pages251-258
Publication size in sheets0.5
Keywords in Englishoxidovanadium(IV), oxydiacetate, thiodiacetate, antioxidant activity, cytoprotective activity, hippocampal HT22 cells
DOIDOI:10.1007/s12011-016-0687-2
URL http://link.springer.com/content/pdf/10.1007%2Fs12011-016-0687-2.pdf
Languageen angielski
Score (nominal)15
ScoreMinisterial score = 15.0, 20-12-2017, ArticleFromJournal
Ministerial score (2013-2016) = 15.0, 20-12-2017, ArticleFromJournal
Publication indicators WoS Impact Factor: 2016 = 2.399 (2) - 2016=2.059 (5)
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