A comprehensive approach to the analysis of antibiotic-metal complexes
Sandra Ramotowska , Małgorzata Wysocka , Jakub Brzeski , Agnieszka Chylewska , Mariusz Makowski
AbstractComplexes of antibiotics with metal ions draw attention of scientists looking for new drugs as well asthose endeavoring to increase the activity of antibiotics that are currently in use. The bioactivity ofantibiotics can be increased by coordination of metal ion. Moreover, such complexes allow for reductionof drug's dose introduced into the body and improve their bioavailability. In order to study the anti-microbial effect of antibiotics-metal complexes, it is necessary to properly determine their structure andphysicochemical properties. Therefore, the selection of appropriate research methods plays a crucial rolein a comprehensive understanding and prediction of metallopharmaceuticals' activity. The electronicstructure and spatial structure of antibiotic-metal complexes, their stability, ligands' donor atoms, acid-base properties, lipophilicity and most preferable binding sites to the biomolecules are essential featuresof this type of compounds. This review delineates the collection of available tools and methods necessaryfor an exhaustive analysis of metallopharmaceuticals.
|Journal series||Trac-Trends in Analytical Chemistry, [TrAC - Trends in Analytical Chemistry], ISSN 0165-9936, e-ISSN 1879-3142, (N/A 140 pkt)|
|Publication size in sheets||0.5|
|Keywords in English||Antibiotic-metal complexes, crystallography, theoretical studies, spectroscopies (1H NMR, CD, UV-Vis), thermogravimetry analysis|
|License||Other; published final; ; with publication|
|Score||= 140.0, 06-02-2020, ArticleFromJournal|
|Publication indicators||: 2017 = 2.004; : 2018 = 8.428 (2) - 2018=8.742 (5)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.