A comprehensive approach to the analysis of antibiotic-metal complexes

Sandra Ramotowska , Małgorzata Wysocka , Jakub Brzeski , Agnieszka Chylewska , Mariusz Makowski

Abstract

Complexes of antibiotics with metal ions draw attention of scientists looking for new drugs as well asthose endeavoring to increase the activity of antibiotics that are currently in use. The bioactivity ofantibiotics can be increased by coordination of metal ion. Moreover, such complexes allow for reductionof drug's dose introduced into the body and improve their bioavailability. In order to study the anti-microbial effect of antibiotics-metal complexes, it is necessary to properly determine their structure andphysicochemical properties. Therefore, the selection of appropriate research methods plays a crucial rolein a comprehensive understanding and prediction of metallopharmaceuticals' activity. The electronicstructure and spatial structure of antibiotic-metal complexes, their stability, ligands' donor atoms, acid-base properties, lipophilicity and most preferable binding sites to the biomolecules are essential featuresof this type of compounds. This review delineates the collection of available tools and methods necessaryfor an exhaustive analysis of metallopharmaceuticals.
Author Sandra Ramotowska (FCh / KChBionieorg. / LII)
Sandra Ramotowska ,,
- Laboratory of Intermolecular Interactions
, Małgorzata Wysocka (FCh / KChBionieorg. / LII)
Małgorzata Wysocka,,
- Laboratory of Intermolecular Interactions
, Jakub Brzeski (FCh / KChBionieorg. / LII)
Jakub Brzeski,,
- Laboratory of Intermolecular Interactions
, Agnieszka Chylewska (FCh / KChBionieorg. / LII)
Agnieszka Chylewska,,
- Laboratory of Intermolecular Interactions
, Mariusz Makowski (FCh / KChBionieorg. / LII)
Mariusz Makowski,,
- Laboratory of Intermolecular Interactions
Journal seriesTrac-Trends in Analytical Chemistry, [TrAC - Trends in Analytical Chemistry], ISSN 0165-9936, e-ISSN 1879-3142, (N/A 140 pkt)
Issue year2020
Vol123
Pages1-9
Publication size in sheets0.5
Article number115771
Keywords in EnglishAntibiotic-metal complexes, crystallography, theoretical studies, spectroscopies (1H NMR, CD, UV-Vis), thermogravimetry analysis
ASJC Classification1602 Analytical Chemistry; 1607 Spectroscopy
DOIDOI:10.1016/j.trac.2019.115771
URL https://doi.org/10.1016/j.trac.2019.115771
Languageen angielski
LicenseOther; published final; Uznanie Autorstwa - Użycie Niekomercyjne - Bez utworów zależnych (CC-BY-NC-ND); with publication
Score (nominal)140
Score sourcejournalList
ScoreMinisterial score = 140.0, 22-05-2020, ArticleFromJournal
Publication indicators Scopus Citations = 0; WoS Citations = 0; Scopus SNIP (Source Normalised Impact per Paper): 2017 = 2.004; WoS Impact Factor: 2018 = 8.428 (2) - 2018=8.742 (5)
Citation count*1 (2020-05-25)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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