The promises and risks of probiotic Bacillus species

Joanna Jeżewska-Frąckowiak , Krystyna Seroczyńska , Justyna Banaszczyk , Gabriela Jędrzejczak , Agnieszka Żylicz-Stachula , Piotr Skowron

Abstract

Supplementing the human microbiome with probiotic microorganisms is a proposed solution for civilization syndromes such as dysbiosis and gastrointestinal tract (GIT) disorders. Bimodal probiotic strains of the Bacillus genus constitute the microbiota of the human environment, and are typically found in soil, water, a number of non-dairy fermented foods, as well as in human and animal GIT. Probiotic Bacillus sp. are Gram positive rods, with the ability of sporulation to survive environmental stress and preparation conditions. In vitro models of the human stomach and human studies with probiotic Bacillus reveal the mechanisms of its life cycle and sporulation. The Bacillus sp. probiotic biofilm introduces biochemical effects such as antimicrobial and enzymatic activity, thus contributing to protection from GIT and other infections. Despite the beneficial activity of Bacillus strains belonging to the safety group 1, a number of strains can pose a substantial health risk, carrying genes for various toxins or antibiotic resistance. Commercially available Bacillus probiotic preparations include strains from the subtilis and other closely related phylogenetic clades. Those intended for oral administration in humans, often encapsulated with appropriate supporting materials, still tend to be mislabeled or poorly characterized. Bacillus sp. MALDI-TOF analysis, combined with sequencing of characteristic 16S rRNA or enzyme coding genes, may provide accurate identification. A promising future application of the probiotic Bacillus sp. might be the microflora biocontrol in the human body and the closest human environment. Environmental probiotic Bacillus species display the potential to support human microflora, however controversies regarding the safety of certain strains is a key factor in their still limited application.
Author Joanna Jeżewska-Frąckowiak (FCh / DMBt / LGE)
Joanna Jeżewska-Frąckowiak,,
- Laboratory of Genetic Engineering
, Krystyna Seroczyńska
Krystyna Seroczyńska,,
-
, Justyna Banaszczyk
Justyna Banaszczyk,,
-
, Gabriela Jędrzejczak
Gabriela Jędrzejczak,,
-
, Agnieszka Żylicz-Stachula (FCh / DMBt / LGE)
Agnieszka Żylicz-Stachula,,
- Laboratory of Genetic Engineering
, Piotr Skowron (FCh / DMBt / LGE)
Piotr Skowron,,
- Laboratory of Genetic Engineering
Journal seriesActa Biochimica Polonica, ISSN 0001-527X, e-ISSN 1734-154X, (A 15 pkt)
Issue year2018
Vol65
No4
Pages509-519
Publication size in sheets0.5
Keywords in EnglishBacillus sp. for detergents, Bacillus sp. probiotic preparation, Bacillus sp. probiotic safety, Bacillus subtilis, biocontrol, human microbiome, probiotic formulations, spore formers
ASJC Classification1300 General Biochemistry, Genetics and Molecular Biology
DOIDOI:10.18388/abp.2018_2652
URL https://ojs.ptbioch.edu.pl/index.php/abp/article/view/2652/1552
Languageen angielski
LicenseJournal (articles only); published final; Other open licence; with publication
Score (nominal)15
ScoreMinisterial score = 15.0, 04-04-2019, ArticleFromJournal
Ministerial score (2013-2016) = 15.0, 04-04-2019, ArticleFromJournal
Publication indicators WoS Citations = 0; Scopus SNIP (Source Normalised Impact per Paper): 2016 = 0.563; WoS Impact Factor: 2017 = 1.239 (2) - 2017=1.541 (5)
Citation count*
Cite
Share Share

Get link to the record


* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
Back