Assessment of the usefulness of bacterial cellulose produced by Gluconacetobacter xylinus E25 as a new biological implant

Magdalena Kołaczkowska , Piotr Siondalski , Maciej Michał Kowalik , Rafał Pęksa , Aldona Długa , Wacław Zając , Paulina Dederko , Ilona Kołodziejska , Edyta Malinowska-Pańczyk , Izabela Sinkiewicz , Hanna Staroszczyk , Agata Śliwińska , Alicja Stanisławska , Marek Szkodo , Paulina Pałczyńska , Grzegorz Jabłoński , Andrzej Borman , Piotr Wilczek

Abstract

Bionanocellulose (BNC) is a clear polymer produced by the bacterium Gluconacetobacter xylinus. In our current study, “Research on the use of bacterial nanocellulose (BNC) in regenerative medicine as a function of the biological implants in cardiac and vascular surgery”, we carried out material analysis, biochemical analysis, in vitro tests and in vivo animal model testing. In stage 1 of the project, we carried out physical and biological tests of BNC. This allowed us to modify subsequent samples of bacterial bionanocellulose. Finally, we obtained a sample that was accepted for testing on an animal model. That sample we define BNC1. Patches of BNC1 were then implanted into pigs' vessel walls. During the surgical procedures, we evaluated the technical aspects of sewing in the bioimplant, paying special attention to bleeding control and tightness of the suture line and the BNC1 bioimplant itself. We carried out studies evaluating the reaction of an animal body to an implantation of BNC1 into the circulatory system, including the general and local inflammatory reaction to the bioimplant. These studies allowed us to document the potential usefulness of BNC as a biological implant of the circulatory system and allowed for additional modifications of the BNC to improve the properties of this new implantable biological material.
Author Magdalena Kołaczkowska
Magdalena Kołaczkowska,,
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, Piotr Siondalski
Piotr Siondalski,,
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, Maciej Michał Kowalik
Maciej Michał Kowalik,,
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, Rafał Pęksa
Rafał Pęksa,,
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, Aldona Długa
Aldona Długa,,
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, Wacław Zając
Wacław Zając,,
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, Paulina Dederko
Paulina Dederko,,
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, Ilona Kołodziejska
Ilona Kołodziejska,,
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, Edyta Malinowska-Pańczyk
Edyta Malinowska-Pańczyk,,
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, Izabela Sinkiewicz
Izabela Sinkiewicz,,
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et al.`
Journal seriesMaterials Science & Engineering C - Materials for Biological Applications, ISSN 0928-4931, (N/A 140 pkt)
Issue year2019
Vol97
Pages302-312
Publication size in sheets0.5
ASJC Classification2210 Mechanical Engineering; 2211 Mechanics of Materials; 3104 Condensed Matter Physics; 2500 General Materials Science
DOIDOI:10.1016/j.msec.2018.12.016
URL https://doi.org/10.1016/j.msec.2018.12.016
Languageen angielski
Score (nominal)140
ScoreMinisterial score = 140.0, 30-09-2019, ArticleFromJournal
Publication indicators WoS Citations = 0; Scopus SNIP (Source Normalised Impact per Paper): 2017 = 1.384; WoS Impact Factor: 2017 = 5.08 (2) - 2017=4.628 (5)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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