Structures, physicochemical and cytoprotective properties of new oxidovanadium(IV) complexes -[VO(mIDA)(dmbipy)]·1.5H2O and [VO(IDA)(dmbipy)]·2H2O

Joanna Drzeżdżon , Dagmara Jacewicz , Dariusz Wyrzykowski , Iwona Inkielewicz-Stępniak , Artur Sikorski , Aleksandra Tesmar , Lech Chmurzyński

Abstract

New oxidovanadium(IV) complexes with a modification of the ligand in the VO2+ coordination sphere were synthesized. [VO(mIDA)(dmbipy)]∙1.5H2O and [VO(IDA)(dmbipy)]∙2H2O were obtained as dark green crystals and grey-green powder, respectively (mIDA = N-methyliminodiacetic anion, IDA = iminodiacetic anion, dmbipy = 4,4′-dimethoxy-2,2′-dipyridyl). The crystal structure of [VO(mIDA)(dmbipy)]·1.5H2O has been determined by the X-ray diffraction method. The studies of structure of [VO(mIDA)(dmbipy)]∙1.5H2O have shown that this compound occurs in the crystal as two rotational conformers. Furthermore, the stability constants of [VO(mIDA)(dmbipy)]∙1.5H2O and [VO(IDA)(dmbipy)]∙2H2O complexes in aqueous solutions were studied by using the potentiometric titration method and, consequently, determined using the Hyperquad2008 program. Moreover, the title complexes were investigated as antioxidant substances. The impact of the structure modification in the VO2+ complexes on the radical scavenging activity has been studied. The ability to scavenge the superoxide radical by two complexes - [VO(mIDA)(dmbipy)]·1.5H2O and [VO(IDA)(dmbipy)]·2H2O was studied by cyclic voltammetry (CV) and nitrobluetetrazolium (NBT) methods. The title complexes were also examined by the spectrophotometric method as scavengers of neutral organic radical - 1,1-diphenyl-2-picrylhydrazyl (DPPH∙) and radical cation - 2,2'-azinobis-(3-ethylbenzothiazoline)-6-sulfonic acid (ABTS∙+). Furthermore, the biological properties of two oxidovanadium(IV) complexes were investigated in relation to its cytoprotective properties by the MTT and LDH tests based on the hippocampal HT22 neuronal cell line during the oxidative damage induced by hydrogen peroxide. Finally, the results presented in this paper have shown that the both new oxidovanadium(IV) complexes with the 4,4′-dimethoxy-2,2′-dipyridyl ligand can be treated as the cytoprotective substances.
Author Joanna Drzeżdżon (FCh / DGICh / LPCC)
Joanna Drzeżdżon,,
- Laboratory of Physicochemistry of Coordination Complexes
, Dagmara Jacewicz (FCh / DGICh / LPCC)
Dagmara Jacewicz,,
- Laboratory of Physicochemistry of Coordination Complexes
, Dariusz Wyrzykowski (FCh / DGICh / PBChN)
Dariusz Wyrzykowski,,
- Pracownia Biologicznej Chemii Nieorganicznej
, Iwona Inkielewicz-Stępniak
Iwona Inkielewicz-Stępniak,,
-
, Artur Sikorski (FCh / DPCh / PK)
Artur Sikorski,,
- Pracownia Krystalochemii
, Aleksandra Tesmar (FCh / DGICh / LPCC)
Aleksandra Tesmar,,
- Laboratory of Physicochemistry of Coordination Complexes
, Lech Chmurzyński (FCh / DGICh / LPCC)
Lech Chmurzyński,,
- Laboratory of Physicochemistry of Coordination Complexes
Journal seriesJournal of Molecular Structure, ISSN 0022-2860, (A 20 pkt)
Issue year2017
Vol1143
Pages515-525
Publication size in sheets0.5
Keywords in Englishoxidovanadium(IV) complexes, radical scavengers, potentiometric titration, 4,4′-dimethoxy-2,2′-dipyridyl, cytoprotective properties
DOIDOI:10.1016/j.molstruc.2017.04.096
URL https://doi.org/10.1016/j.molstruc.2017.04.096
Languageen angielski
Score (nominal)20
ScoreMinisterial score = 20.0, 20-12-2017, ArticleFromJournal
Ministerial score (2013-2016) = 20.0, 20-12-2017, ArticleFromJournal
Publication indicators WoS Impact Factor: 2016 = 1.753 (2) - 2016=1.561 (5)
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