Evaluation of bioconcentration and metabolism of diclofenac in mussels Mytilus trossulus - laboratory study

Klaudia Świacka , Anna Szaniawska , Magda Caban

Abstract

Interest in the presence of pharmaceutically active compounds in the aquatic environment has been growing for over 20 years, yet very few studies deal with the metabolism of pharmaceuticals in marine organisms. In this study, the bioaccumulation under short-term conditions and metabolism of diclofenac were investigated. Mytilus trossulus was used as a representative of the Baltic benthic fauna. The mussels were exposed to diclofenac at a concentration of 133.33 μg/L for five days, following a five-day depuration phase. The highest concentration of diclofenac (7.79 μg/g dw) in tissues was determined on day 3. Subsequently, the concentration of diclofenac in tissues decreased rapidly to 0.86 μg/g dw on day 5. After five days of depuration, the concentration of diclofenac was 0.21 μg/g dw. Hydroxylated diclofenac metabolites were found both in tissues of mussels and water. This study shows that M. trossulus has the potential to accumulate diclofenac and metabolize it to 4-OH and 5-OH diclofenac.
Author Klaudia Świacka (FOG)
Klaudia Świacka,,
- Faculty of Oceanography and Geography
, Anna Szaniawska (FOG / IO / DEEMO)
Anna Szaniawska,,
- Division of Experimental Ecology of Marine Organisms
, Magda Caban (FCh / DEA / PAiMŚ)
Magda Caban,,
- Pracownia Analityki i Monitoringu Środowiska
Journal seriesMarine Pollution Bulletin, ISSN 0025-326X, (A 40 pkt)
Issue year2019
Vol141
Pages249-255
Publication size in sheets0.5
Keywords in EnglishMytilus trossulus, mussels, Baltic Sea, bioaccumulation, bioconcentration, diclofenac
ASJC Classification2310 Pollution; 1104 Aquatic Science; 1910 Oceanography
DOIDOI:10.1016/j.marpolbul.2019.02.050
URL https://doi.org/10.1016/j.marpolbul.2019.02.050
Languageen angielski
Score (nominal)40
ScoreMinisterial score = 40.0, 24-07-2019, ArticleFromJournal
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2017 = 1.228; WoS Impact Factor: 2017 = 3.241 (2) - 2017=3.767 (5)
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