Evaluation of bioconcentration and metabolism of diclofenac in mussels Mytilus trossulus - laboratory study
Klaudia Świacka , Anna Szaniawska , Magda Caban
AbstractInterest in the presence of pharmaceutically active compounds in the aquatic environment has been growing for over 20 years, yet very few studies deal with the metabolism of pharmaceuticals in marine organisms. In this study, the bioaccumulation under short-term conditions and metabolism of diclofenac were investigated. Mytilus trossulus was used as a representative of the Baltic benthic fauna. The mussels were exposed to diclofenac at a concentration of 133.33 μg/L for five days, following a five-day depuration phase. The highest concentration of diclofenac (7.79 μg/g dw) in tissues was determined on day 3. Subsequently, the concentration of diclofenac in tissues decreased rapidly to 0.86 μg/g dw on day 5. After five days of depuration, the concentration of diclofenac was 0.21 μg/g dw. Hydroxylated diclofenac metabolites were found both in tissues of mussels and water. This study shows that M. trossulus has the potential to accumulate diclofenac and metabolize it to 4-OH and 5-OH diclofenac.
|Journal series||Marine Pollution Bulletin, ISSN 0025-326X, (N/A 100 pkt)|
|Publication size in sheets||0.50|
|Keywords in English||Mytilus trossulus, mussels, Baltic Sea, bioaccumulation, bioconcentration, diclofenac|
|ASJC Classification||; ;|
|Score||= 100.0, 28-01-2020, ArticleFromJournal|
|Publication indicators||= 1.000; : 2017 = 1.228; : 2018 = 3.782 (2) - 2018=4.349 (5)|
|Citation count*||9 (2020-07-03)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.