The landscape of circulating tumor cell research in the context of epithelial-mesenchymal transition

Aleksandra Markiewicz , Anna Żaczek

Abstract

The metastatic spread of cancer accounts for the vast majority of cancer-related deaths. It is mediated by tumor cells circulating in blood (called circulating tumor cells, CTCs), which escaped from their established niches. CTCs give a unique opportunity to look into the metastatic cascade and to study the molecular processes supporting the spread of tumor cells throughout the body. As current therapies are not sufficiently effective in treating metastatic disease, it is important to determine cellular and molecular features of cancer cells that “seed” new tumors in distant organs at early stages. In this review we focus on the role of the epithelial-mesen-chymal transition program in providing a survival advantage to metastasizing tumor cells, especially CTCs, and put it in the context of clinical findings.
Author Aleksandra Markiewicz (IFB)
Aleksandra Markiewicz,,
- Intercollegiate Faculty of Biotechnology UG
, Anna Żaczek (IFB / DMedB)
Anna Żaczek,,
- Department of Medical Biotechnology
Journal seriesPathobiology, ISSN 1015-2008, (A 20 pkt)
Issue year2017
Vol84
No5
Pages264-283
Publication size in sheets0.95
Keywords in Englishcirculating tumor cells, epithelial-mesenchymal transition, associated phenotypes, metastasis, dissemination, prognostic markers, predictive markers
DOIDOI:10.1159/000477812
URL https://www.karger.com/Article/Pdf/477812
Languageen angielski
Score (nominal)25
ScoreMinisterial score = 20.0, 26-01-2018, ArticleFromJournal
Ministerial score (2013-2016) = 25.0, 26-01-2018, ArticleFromJournal
Publication indicators WoS Impact Factor: 2016 = 1.703 (2) - 2016=1.8 (5)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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