Selective cytotoxicity of vanadium complexes on human pancreatic ductal adenocarcinoma cell line by inducing necroptosis, apoptosis and mitotic catastrophe process

Szymon Kowalski , Stanisław Hać , Dariusz Wyrzykowski , Agata Zauszkiewicz-Pawlak , Iwona Inkielewicz-Stępniak

Abstract

The pancreatic cancer is the fourth leading cause of cancer-related death and characterized by one of the lowest five-year survival rate. The current therapeutic options are demonstrating minimal effectiveness, therefore studies on new potential anticancer compounds, with non-significant side effects are highly desirable. Recently, it was demonstrated that vanadium compounds, in particular organic derivatives, exhibit anticancer properties against different type of tumor as well as favorable biodistribution from a pancreatic cancer treatment perspective.In this research, we showed selective cytotoxic effect of vanadium complexes, containing phenanthroline and quinoline as an organic ligands, against human pancreatic ductal adenocarcinoma cell line (PANC-1), compared to non-tumor human immortalized pancreas duct epithelial cells (hTERT-HPNE). Results exhibited that vanadium complexes inhibited autophagy process in selective cytotoxic concentration as well as caused the cell cycle arrest in G2/M phase associated with mitotic catastrophe and increased level of reactive oxygen species (ROS). Moreover, in higher concentration, vanadium derivatives induced a mix type of cell death in PANC-1 cells, including apoptotic and necroptotic process.Our investigation emphasizes the anticancer potential of vanadium complexes by indicating their selective cytotoxic activity, through different process posed by alternative type of cell deaths to apoptosis-resistant cancer cells. Further studies supporting the therapeutic potential of vanadium in pancreatic cancer treatment is highly recommended.
Author Szymon Kowalski
Szymon Kowalski,,
-
, Stanisław Hać
Stanisław Hać,,
-
, Dariusz Wyrzykowski PBChN
Dariusz Wyrzykowski,,
- Pracownia Biologicznej Chemii Nieorganicznej
, Agata Zauszkiewicz-Pawlak
Agata Zauszkiewicz-Pawlak,,
-
, Iwona Inkielewicz-Stępniak
Iwona Inkielewicz-Stępniak,,
-
Journal seriesOncotarget, ISSN 1949-2553
Issue year2017
Vol8
No36
Pages60324-60341
Publication size in sheets0.85
Keywords in Englishvanadium complexes, pancreatic cancer, necroptosis, mitotic catastrophe, autophagy
DOIDOI:10.18632/oncotarget.19454
URL https://doi.org/10.18632/oncotarget.19454
Languageen angielski
LicenseJournal (articles only); published final; Uznanie Autorstwa (CC-BY); with publication
Score (nominal)40
ScoreMinisterial score = 35.0, 20-12-2017, ArticleFromJournal
Ministerial score (2013-2016) = 40.0, 20-12-2017, ArticleFromJournal
Publication indicators WoS Impact Factor: 2016 = 5.168 (2) - 2016=5.312 (5)
Citation count*0
Cite
Share Share

Get link to the record
msginfo.png


* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
Back